DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7536 and XPR1

DIOPT Version :9

Sequence 1:	NP_001285398.1	Gene:	CG7536 / 32786	FlyBaseID:	FBgn0030890	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_004727.2	Gene:	XPR1 / 9213	HGNCID:	12827	Length:	696	Species:	Homo sapiens

Alignment Length:	697	Identity:	381/697 - (54%)
Similarity:	486/697 - (69%)	Gaps:	29/697 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLSAHITPEWRKQYINYEEMKAMLYLAVEEAPSVESVEDDVLKRHFANFDENFFHYCDKE 65
            ||||||||||||||||||||.||..|.|||.|.::|||||..::|.:||:||.|:|.||..|:||
Human     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LKKINTFYSEKLAEATRKFATLNAELKTSIEESE--------RSAKKSKGHKRH-AALPDRKARE 121
            |.|||||||||||||.|:||||..||::|::..:        |..:|...|..| ..:..|..::
Human    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKD 130

  Fly   122 LKLAFSEFYLSLILLQNYQNLNHTGFRKILKKHDKLLRVDTGAKWRQEYVEASHFFTNKDIDNII 186
            ||||||||||||||||||||||.||||||||||||:|....||.||..:||.:.|:|.|.|:.:|
Human   131 LKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLI 195

  Fly   187 NETETTVTGELEGGDRQRAMKRLRVPPLG-EQQSP-WTTFKVGLFSGSFIVLVIVVVVSAIFHEI 249
            :|||..||.|||.||||:||||||||||| .|.:| ||||:||||.|.||||.|.:|::|:|...
Human   196 SETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLE 260

  Fly   250 SGENLKVTFRLYRGPLLIIEFIFLIGVNIYGWRSSGVNHVLIFELDPRNHLSEQHLMELAAIFGV 314
            :..::....|:|||..|:|||:||:|:|.||||.:||||||||||:||::||.|||.|:|...|:
Human   261 TDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGI 325

  Fly   315 IWTLSMLSFLYSASLAIPAFINPLTLTLIMVLFLANPFHVLYHDARFWLWRITGRCVSAPFFHVG 379
            :|.||:|:..::....||.::.||.|...||.||.||....|:.:||||.::..|..:|||..||
Human   326 LWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVG 390

  Fly   380 FADFWLGDQLNSLATAILDFEYLICFYFTNGNWTEAR--------DASICMEKDFIIRPIVNCLP 436
            ||||||.||||||:..::|.||:||||.....|.|::        ::.||.:..:.:|.||.|:|
Human   391 FADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIP 455

  Fly   437 AWFRFAQCLRRYRDSREAFPHLVNAGKYSTTFMVVIFATLKSFHSP-NYASTFDNPYTWLWIIAS 500
            ||.||.||||||||::.|||||||||||||||.:|.||.|.|.|.. .::.|.  .:.:|||:..
Human   456 AWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTM--VFFYLWIVFY 518

  Fly   501 IVSSCYAYTWDIKMDWGLFDKNAGENTFLREEVVYSSTGFYYFAILEDLALRFIWALSFYLTEMK 565
            |:||||...||:||||||||||||||||||||:||....:||.||:||:.|||.|.:...:|...
Human   519 IISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTT 583

  Fly   566 IV--SSDIMTSVTGILEVFRRFVWNFFRLENEHLNNCGKFRAVRDISIAPLDSSDQALILRLMDE 628
            ::  |.||:.:|...|||||||||||||||||||||||:||||||||:|||::.||.|:.::||:
Human   584 LLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQ 648

  Fly   629 ADGVINRYTKANRPKPKKVKDPEKRSLLQTRGSLPDLRI---DMDSK 672
            .|||.||  :.||..........:|..|.::....|.::   |.|.:
Human   649 DDGVRNR--QKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDE 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7536	NP_001285398.1	SPX_XPR1_like	2..156	CDD:269898	102/162 (63%)
		SPX	3..158	CDD:281146	103/163 (63%)
		EXS	258..597	CDD:281164	188/349 (54%)
XPR1	NP_004727.2	SPX_XPR1_like	2..165	CDD:269898	102/162 (63%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	158..165		6/6 (100%)
		EXS	268..617	CDD:367343	188/350 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..696		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	402	1.000	Domainoid score	I732
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	749	1.000	Inparanoid score	I579
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		otm41780
orthoMCL	1	0.900	-	-		OOG6_100965
Panther	1	1.100	-	-	LDO	PTHR10783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1440
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820