DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7536 and SYG1

DIOPT Version :9

Sequence 1:	NP_001285398.1	Gene:	CG7536 / 32786	FlyBaseID:	FBgn0030890	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_012217.3	Gene:	SYG1 / 854764	SGDID:	S000001309	Length:	902	Species:	Saccharomyces cerevisiae

Alignment Length:	849	Identity:	215/849 - (25%)
Similarity:	326/849 - (38%)	Gaps:	261/849 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLSAHITPEWRKQYINYEEMKAML-----YLAVEE---------APSV------------ 39
            ||||:||:....||||.:||:|:..|..|     .|..||         .|||
Yeast     1 MKFADHLTESAIPEWRDKYIDYKVGKKKLRRYKEKLDAEEEQSSSYRSWMPSVSVYQTAFQQREP 65

  Fly    40 -ESVED-------------DVLKRHF-ANFDENFFHYCDKELKKINTFYSEKLAEATRKFATLNA 89
             :|..|             ..|:|.| |:|.|::.  ...:|.|.|.||...|.|..:||..|.:
Yeast    66 GKSRSDGDYRSGPAFKKDYSALQREFVADFIEDWL--ISFQLSKCNEFYLWLLKECDKKFEVLQS 128

  Fly    90 ELK---------------------------------------TSIEESERS-----------AKK 104
            :|.                                       .||:...||           |||
Yeast   129 QLHYYSLQKNYERDNLNRSSSNVDMSTSLYAAGLAGRSDSRVNSIDSDSRSVMYGSMPCTKEAKK 193

  Fly   105 --------------------------------------SKGHKRHA-------ALPDRKARE-LK 123
                                                  |:|.:..|       .:...:||. |.
Yeast   194 PRLSLLAYCQKVLKDNRLLPSWPKRGFSLLQDLRQDASSRGRETFAFGASFLETMTTTQARNLLS 258

  Fly   124 LAFSEFYLSLILLQNYQNLNHTGFRKILKKHDKLLRVDTGAKWRQEYVEASHFFTNKDID-NI-- 185
            .|..|:||.|.|:::::::|.|||||::||.||.........: ..|.. :|:...|..| |:
Yeast   259 NAIIEYYLYLQLVKSFRDINVTGFRKMVKKFDKTCHTRELTTF-MSYAR-THYTLFKHADANVQL 321

  Fly   186 -------INETETTVTGELEGGDRQR------------------------------AMKRLRVP- 212
                   |..::.|.|.||....|.:                              .:|:|.:.
Yeast   322 VAQKMQQITSSQPTPTSELSSAQRDKEPITWLETQITEWFTTALTNSPKDRKHNTHKLKKLTIQY 386

  Fly   213 PLGEQ------QSPWTTFKVGLFSGSFIVLVIVVVVSAIFHEISGENLKVTFRLYRG--PLLIIE 269
            .:.||      :|......|||..|..:.|:...:...|..|.:....|:.|.|:.|  .:|:|.
Yeast   387 SISEQMVHRNNRSIVQMLVVGLGIGVSMTLITYTLYLGISSEETSFTHKILFPLWGGWYMVLLIA 451

  Fly   270 FIFLIGVNIYGWRSSGVNH--VLIFELDPRN---------HLSEQHLMELAAIFGVI--WTLSML 321
            |:||  ||.:.|..:|:|:  :::.|:..:|         ..|:..|......|.::  ...|||
Yeast   452 FLFL--VNCFIWHRTGINYRFIMLGEIQSKNGTQFFNNDFATSKIPLKLYFLTFFIVPCAVCSML 514

  Fly   322 SFLYSASLAIPAFINP---LTLTLIMVLFLANPFHVLYHD----ARFWLWRITGRCVSAPFFHVG 379
            ||....       :.|   |.:.::..|||.....:.|.|    .|.||.....|.:.:.||.|.
Yeast   515 SFALEK-------LTPLGFLYIGIVSFLFLCPSGLIPYWDKVVHTRKWLVVTLIRLMMSGFFPVE 572

  Fly   380 FADFWLGDQLNSLATAILDFEYLICFYFTNGNWTEARDASICMEKDFIIRPIVNCLPAWFRFAQC 444
            |.||:|||.:.||..:|.|.....|.|....|       ::|.........:::|||:::||.||
Yeast   573 FGDFFLGDIICSLTYSIADIAMFFCVYSHTPN-------NLCGSSHSRAMGVLSCLPSYWRFMQC 630

  Fly   445 LRRYRDSREAFPHLVNAGKYSTTFMVVIFATLKSFHSPNYASTFDNPYTWLWIIASIVSSCYAYT 509
            |||:.||.:.||||:||.||  |..:...|||.::...:.:.....|:    |:.:.::|.....
Yeast   631 LRRFADSGDWFPHLLNAAKY--TLGIAYNATLCAYRLSDRSEQRRTPF----IVCATLNSILTSA 689

  Fly   510 WDIKMDWGLFDKNAGENTFLREEVV-------------YSSTGFYYFAILEDLALRFIWALSFYL 561
            ||:.|||.........|..||:::.             :|....||||::.|:.:||.| :.:.:
Yeast   690 WDLVMDWSFAHNTTSYNWLLRDDLYLAGKKNWENGSYSFSRKLVYYFAMIWDILIRFEW-IVYAI 753

  Fly   562 TEMKIVSSDIMTSVTGILEVFRRFVWNFFRLENEHLNNCGKFRAVRDISIAPL------------ 614
            ....|..|.:.:.:..:|||.|||||..||:||||:.|...||...|   |||
Yeast   754 APQTIQQSAVTSFILALLEVLRRFVWIIFRVENEHVANVHLFRVTGD---APLPYPIAQVGDDSM 815

  Fly   615 DSSD 618
            ||||
Yeast   816 DSSD 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7536	NP_001285398.1	SPX_XPR1_like	2..156	CDD:269898	66/290 (23%)
		SPX	3..158	CDD:281146	67/291 (23%)
		EXS	258..597	CDD:281164	110/373 (29%)
SYG1	NP_012217.3	COG5408	1..310	CDD:227695	71/312 (23%)
SYG1	NP_012217.3	COG5409	402..803	CDD:227696	124/426 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I970
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I809
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		otm46759
orthoMCL	1	0.900	-	-		OOG6_100965
Panther	1	1.100	-	-	LDO	PTHR10783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1440
SonicParanoid	1	1.000	-	-		X439
TreeFam	1	0.960	-	-
	13	12.800