DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7536 and VTC4

DIOPT Version :9

Sequence 1:	NP_001285398.1	Gene:	CG7536 / 32786	FlyBaseID:	FBgn0030890	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_012522.2	Gene:	VTC4 / 853441	SGDID:	S000003549	Length:	721	Species:	Saccharomyces cerevisiae

Alignment Length:	232	Identity:	57/232 - (24%)
Similarity:	98/232 - (42%)	Gaps:	60/232 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLSAHITPEWRKQYINYEEMKAMLYLAVEEAPSVESVEDDVLKRH---FANFDENFFHYC 62
            |||.||||..:..::...||:|:::|..|             ||::.|.:   ....:.:|....
Yeast     1 MKFGEHLSKSLIRQYSYYYISYDDLKTEL-------------EDNLSKNNGQWTQELETDFLESL 52

  Fly    63 DKELKKINTFYSEKLAEATRKFATLNAELKTSIEESERSAKKSKGHKRHAALPDRKARELKLAFS 127
            :.||.|:.||...|.:|..|:.    .|::..::.:.|             |.|......:|.|.
Yeast    53 EIELDKVYTFCKVKHSEVFRRV----KEVQEQVQHTVR-------------LLDSNNPPTQLDFE 100

  Fly   128 --EFYLSLIL-----LQNYQNLNHTGFRKILKKHDK----------LLRVDTGAKWRQEY----V 171
              |..||.|:     |..:..||:|||:||:|||||          .:|:|:...:::.|    |
Yeast   101 ILEEELSDIIADVHDLAKFSRLNYTGFQKIIKKHDKKTGFILKPVFQVRLDSKPFFKENYDELVV 165

  Fly   172 EASHFFTNKDIDNIINETETTVTGELEGGDRQRAMKR 208
            :.|..:      :|...:...:.|:...|.:|:...|
Yeast   166 KISQLY------DIARTSGRPIKGDSSAGGKQQNFVR 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7536	NP_001285398.1	SPX_XPR1_like	2..156	CDD:269898	44/163 (27%)
		SPX	3..158	CDD:281146	45/174 (26%)
		EXS	258..597	CDD:281164
VTC4	NP_012522.2	COG5036	1..497	CDD:227369	57/232 (25%)
VTC4	NP_012522.2	DUF202	593..721	CDD:415817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.790