DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7536 and xpr1b

DIOPT Version :9

Sequence 1:	NP_001285398.1	Gene:	CG7536 / 32786	FlyBaseID:	FBgn0030890	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001119862.1	Gene:	xpr1b / 558034	ZFINID:	ZDB-GENE-060503-266	Length:	693	Species:	Danio rerio

Alignment Length:	688	Identity:	381/688 - (55%)
Similarity:	482/688 - (70%)	Gaps:	46/688 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLSAHITPEWRKQYINYEEMKAMLYLAVEEAPSVESVEDDVLKRHFANFDENFFHYCDKE 65
            |||.||||||||||||||||.||..|.|||.|.::|||:|..::|.:||::|.|:|.||..|:||
Zfish     1 MKFTEHLSAHITPEWRKQYIQYEAFKEMLYSAQDQAPSIEVTDEDTVKRYYAKFEEKFFQTCEKE 65

  Fly    66 LKKINTFYSEKLAEATRKFATLNAELKTSIEESERSAKKSKG--HKR---HAALPD----RKARE 121
            |.|||||||||||||.|:||||..||::|: :::|.:.::.|  |:|   |.:..:    |..::
Zfish    66 LAKINTFYSEKLAEAQRRFATLQNELQSSL-DAQRESSRAAGLRHRRTVFHLSQQERCKHRNIKD 129

  Fly   122 LKLAFSEFYLSLILLQNYQNLNHTGFRKILKKHDKLLRVDTGAKWRQEYVEASHFFTNKDIDNII 186
            |:||||||||||||||||||||.||||||||||||:.....||.||..:||.:.|:|.|.|..:|
Zfish   130 LQLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKIFETSRGADWRVAHVEVAPFYTCKKITQLI 194

  Fly   187 NETETTVTGELEGGDRQRAMKRLRVPPLG-EQQSP-WTTFKVGLFSGSFIVLVIVVVVSAIFH-- 247
            :||||.||.||||||||:||||||||||| .|.:| ||||:|||:.|.|:.|.:.|:::.:..
Zfish   195 SETETLVTTELEGGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLYCGVFVALTVTVIIAGVVKLV 259

  Fly   248 EISGENLKV--TFRLYRGPLLIIEFIFLIGVNIYGWRSSGVNHVLIFELDPRNHLSEQHLMELAA 310
            |..|:|..|  ..|:|||..|:|||:||:|:|.||||.:||||||||||:|||:||.|||.|:|.
Zfish   260 EHFGDNTDVWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAG 324

  Fly   311 IFGVIWTLSMLSFLYSASLAIPAFINPLTLTLIMVLFLANPFHVLYHDARFWLWRITGRCVSAPF 375
            ..||:|.:|:||.|::.:..||..:|||.|.....|||.||....|:.:||||.::..|.|:|||
Zfish   325 FLGVLWCVSILSCLFAENTLIPIHMNPLALYGFFFLFLINPLKTCYYKSRFWLLKLLFRVVTAPF 389

  Fly   376 FHVGFADFWLGDQLNSLATAILDFEYLICFYFTNGNWTEA-------RDASICMEKDFIIRPIVN 433
            ..||||||||.||||||...::|.||:||||....|||.:       ....||....:.:|.::.
Zfish   390 HRVGFADFWLADQLNSLVVVLMDLEYMICFYSLELNWTMSEGELWIKEGERICYSYSYGVRAVIK 454

  Fly   434 CLPAWFRFAQCLRRYRDSREAFPHLVNAGKYSTTFMVVIFATLKSFHSPNYASTFDNPYTWLWII 498
            ||||||||.||||||||::.|||||||||||||||.||||..|...||.      |..:.:|:|:
Zfish   455 CLPAWFRFVQCLRRYRDTKRAFPHLVNAGKYSTTFFVVIFEALFKTHSG------DERFVFLYIM 513

  Fly   499 AS--IVSSCYAYTWDIKMDWGLFDKNAGENTFLREEVVYSSTGFYYFAILEDLALRFIWA--LSF 559
            .:  ||:|||...||:||||||||:||||||.||||:||....:||.||:||:.|||.|.  ||.
Zfish   514 IACRIVNSCYTLLWDLKMDWGLFDRNAGENTLLREEIVYPQKAYYYCAIVEDVILRFAWTIPLSL 578

  Fly   560 YLTEMKIVSSDIMTSVTGILEVFRRFVWNFFRLENEHLNNCGKFRAVRDISIAPLDSSDQALILR 624
            .:...:.|.|:|:.:|...|||||||||||||||||||||||:||||||||:|||::.||.|:.:
Zfish   579 EVVYDRPVISNILGTVLPPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQ 643

  Fly   625 LMDEADGVINRYTKAN----------RPK---PKKVKD 649
            :||:.|||.||..|.|          ||:   ..||:|
Zfish   644 MMDQEDGVRNRLGKKNWKRSYSMSLRRPRLSSQSKVRD 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7536	NP_001285398.1	SPX_XPR1_like	2..156	CDD:269898	99/162 (61%)
		SPX	3..158	CDD:281146	100/163 (61%)
		EXS	258..597	CDD:281164	192/349 (55%)
xpr1b	NP_001119862.1	SPX_XPR1_like	2..164	CDD:269898	99/162 (61%)
		SPX	3..172	CDD:281146	100/169 (59%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	157..164		6/6 (100%)
		EXS	289..616	CDD:281164	182/332 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..693		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578006
Domainoid	1	1.000	397	1.000	Domainoid score	I719
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129026
Inparanoid	1	1.050	740	1.000	Inparanoid score	I577
OMA	1	1.010	-	-		QHG54286
OrthoDB	1	1.010	-	-		D125160at33208
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		mtm6598
orthoMCL	1	0.900	-	-		OOG6_100965
Panther	1	1.100	-	-	O	PTHR10783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1440
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800