DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7536 and Xpr1

DIOPT Version :9

Sequence 1:	NP_001285398.1	Gene:	CG7536 / 32786	FlyBaseID:	FBgn0030890	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_035403.1	Gene:	Xpr1 / 19775	MGIID:	97932	Length:	695	Species:	Mus musculus

Alignment Length:	696	Identity:	381/696 - (54%)
Similarity:	480/696 - (68%)	Gaps:	28/696 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFAEHLSAHITPEWRKQYINYEEMKAMLYLAVEEAPSVESVEDDVLKRHFANFDENFFHYCDKE 65
            ||||||||||||||||||||.||..|.|||.|.::|||||..::|.:||:||.|:|.||..|:||
Mouse     1 MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKE 65

  Fly    66 LKKINTFYSEKLAEATRKFATLNAELKTSIEESERSA--------KKSKGHKRH-AALPDRKARE 121
            |.|||||||||||||.|:||||..||::|::..:.|:        :|...|..| ..:..|..::
Mouse    66 LAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSGVTTLRQRRKPVFHLSHEERVQHRNIKD 130

  Fly   122 LKLAFSEFYLSLILLQNYQNLNHTGFRKILKKHDKLLRVDTGAKWRQEYVEASHFFTNKDIDNII 186
            ||||||||||||||||||||||.||||||||||||:|....||.||..:||.:.|:|.|.|:.:|
Mouse   131 LKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKKINQLI 195

  Fly   187 NETETTVTGELEGGDRQRAMKRLRVPPLG-EQQSP-WTTFKVGLFSGSFIVLVIVVVVSAIFHEI 249
            :|||..||.|||.||||:||||||||||| .|.:| ||||:||||.|.||||.|.:|.:|:|...
Mouse   196 SETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVFAAVFKLE 260

  Fly   250 SGENLKVTFRLYRGPLLIIEFIFLIGVNIYGWRSSGVNHVLIFELDPRNHLSEQHLMELAAIFGV 314
            :...:....|:|||..|:|||:||:|:|.||||.:||||||||||:|||:||.|||.|:|...|:
Mouse   261 TDRTVWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGI 325

  Fly   315 IWTLSMLSFLYSASLAIPAFINPLTLTLIMVLFLANPFHVLYHDARFWLWRITGRCVSAPFFHVG 379
            :|.||:|:..::....||.::.||.|...||.||.||....|:.:||||.::..|..:|||..||
Mouse   326 LWCLSLLACFFAPISIIPIYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVG 390

  Fly   380 FADFWLGDQLNSLATAILDFEYLICFYFTNGNWTEAR--------DASICMEKDFIIRPIVNCLP 436
            ||||||.||||||:..::|.||:||||.....|.|::        :...|.:..:.:|.||.|:|
Mouse   391 FADFWLADQLNSLSVILMDLEYMICFYSFELKWDESKGLLPNDPQEPEFCHKYSYGVRAIVQCIP 455

  Fly   437 AWFRFAQCLRRYRDSREAFPHLVNAGKYSTTFMVVIFATLKSFH-SPNYASTFDNPYTWLWIIAS 500
            ||.||.||||||||:|.|||||||||||||||..|.||.|.|.| ..|::.|.  .:.:||:...
Mouse   456 AWLRFIQCLRRYRDTRRAFPHLVNAGKYSTTFFTVTFAALYSTHEEQNHSDTV--VFFYLWVFFC 518

  Fly   501 IVSSCYAYTWDIKMDWGLFDKNAGENTFLREEVVYSSTGFYYFAILEDLALRFIWALSFYLT-EM 564
            |:||||...||:||||||||||||||||||||:||....:||.||:||:.|||.|.:...:| ..
Mouse   519 IISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITATF 583

  Fly   565 KIVSSDIMTSVTGILEVFRRFVWNFFRLENEHLNNCGKFRAVRDISIAPLDSSDQALILRLMDEA 629
            |....:|:.:|...|||||||||||||||||||||||:||||||||:|||::.||.|:.::||:.
Mouse   584 KPHVGNIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQE 648

  Fly   630 DGVINRYTKANRPKPKKVKDPEKRSLLQTRGSLPDLRI---DMDSK 672
            |||.||  :.||..........:|..|.::....|.::   |.|.:
Mouse   649 DGVRNR--QKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDE 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7536	NP_001285398.1	SPX_XPR1_like	2..156	CDD:269898	102/162 (63%)
		SPX	3..158	CDD:281146	103/163 (63%)
		EXS	258..597	CDD:281164	188/348 (54%)
Xpr1	NP_035403.1	SPX_XPR1_like	2..165	CDD:269898	102/162 (63%)
		SPX	3..169	CDD:281146	104/165 (63%)
		Important for inositol polyphosphate binding. /evidence=ECO:0000250\|UniProtKB:P43585	158..165		6/6 (100%)
		EXS	286..616	CDD:281164	178/331 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..695		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I748
eggNOG	1	0.900	-	-		E1_COG5409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	744	1.000	Inparanoid score	I588
Isobase	1	0.950	-	0.569298	Normalized mean entropy	S1995
OMA	1	1.010	-	-		QHG54286
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000547
OrthoInspector	1	1.000	-	-		otm43832
orthoMCL	1	0.900	-	-		OOG6_100965
Panther	1	1.100	-	-	LDO	PTHR10783
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1440
SonicParanoid	1	1.000	-	-		X439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810