DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc16F and DNAH7

DIOPT Version :9

Sequence 1:	NP_523394.1	Gene:	Dhc16F / 32785	FlyBaseID:	FBgn0283476	Length:	4081	Species:	Drosophila melanogaster
Sequence 2:	NP_061720.2	Gene:	DNAH7 / 56171	HGNCID:	18661	Length:	4024	Species:	Homo sapiens

Alignment Length:	4316	Identity:	1467/4316 - (33%)
Similarity:	2253/4316 - (52%)	Gaps:	548/4316 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ISKGKDRSKIKIKGKE---------KEKERKKDEDDDGSRKARERGRSRRQSAGGGDH------S 58
            :|..:|:|..|.|.|:         .||...|::     .||..|...:........|      |
Human     1 MSSEQDKSASKEKSKKPVRFLPQLSMEKLASKEK-----FKAPARALPQLSMVSTKPHWQQAAPS 60

  Fly    59 VDMGFKRVTGEDRPSSMSMDRLDSDFAAFTDRASDAN------DGSITGPADGNGKKAQTGGKQK 117
            ..:..|:  .::.|...|: :.:...|.:.:|.....      |.|..||
Human    61 FHLSVKQ--DDESPEPFSV-KNEQSHAEYMERFGKKGKLPHQVDDSYVGP--------------- 107

  Fly   118 RASKHRLNFSTSKSAGSGTGNKSRSASTTKITTGASLIPDLNLIINRMRNMPDDSFVYMDYMLPH 182
                     |||||.|.....:..:..:|.:........||:..:      ||.|.:
Human   108 ---------STSKSKGKSPHKERENFRSTLVNVIMQQDADLDSAV------PDGSTI-------- 149

  Fly   183 DSEYFTPYSLREVEYKDLNTYEPFYTVTRHGVTFWHCSENFFTPL-DQWQQEFKQFLSIIQIRSF 246
                  |........||:..|   |....||:...|.:     |: |.|   .:..|.::.
Human   150 ------PKPTASAIEKDILRY---YYYIHHGIDTDHVA-----PMEDSW---LEHVLDLVP---- 193

  Fly   247 SIFRLWKGFKVWEKTIKWRKLNEARDYLQNNLFIVIPQLAKAILRMRSDIVQL------------ 299
                  :..||:..:|.........|||               |.:|..||..
Human   194 ------QHLKVFTDSIVTLSDEMREDYL---------------LSVRKSIVDFVLKDPREKGDDK 237

  Fly   300 ------------------QRLNFVNVSNIENWHPFYFLETHMRIYEQLHKTFTDFREFIAKTIFR 346
                              .|.:|:..|:....|......|.:.:.:..|..|...|....|. |.
Human   238 KTDELPAHRAEMEILPKPWRKSFLAASSYIRDHLNAMNPTMLAVLDLWHTNFKKLRLVDIKE-FH 301

  Fly   347 ACTDAIQARGF-------------------YPDDEVNYYPSLKKMREAHSFMDRARKRAFCKTLT 392
            .|.||::...|                   :|:.:..||...|| ::..:....|:..:|.....
Human   302 NCQDALELSSFQNIIMRHMDSAKETLLKMWFPEVQNIYYQGNKK-KQLPTGDSSAKLESFFNCAA 365

  Fly   393 NFLTYCDMMVYQMLYRITKKSFEDLATSFEVHDEVGPSEADINKHDRVDKRIEKQRPQDKPQS-- 455
            ..:|    :..|.|..::.:.|.||..                            :|.|..::
Human   366 ALMT----LQLQDLTLVSMQDFTDLIA----------------------------QPPDSVRAFE 398

  Fly   456 -PFFLAMLRLLPDRIDIEPSEDIIRIIFQRITGLILETVLEIHPFTTDPFFTQYTQPSIMGRQEE 519
             |.|:..|.|..|.|..||.......||..:..::::.|                  |.:.|.|.
Human   399 HPGFIMRLILDNDTIKFEPELSDYIDIFLNVYDVMIKAV------------------SFVPRVET 445

  Fly   520 VLY-----EGAP-DLHYLLRADIRFQYNRKNMFVLIRKAY---ERARLY-------TQRFHQIRE 568
            .||     :..| .|..::..:|...:..|...|:::::.   |..|||       |::..:..:
Human   446 KLYSKWESKSKPTTLKPIILNEIVDAHKEKIKEVIMKESVAPTEHLRLYDKYDFLITRKAERDVD 510

  Fly   569 NFEIDNSTDPTVLNTERDLQILRAYCDRYCNNVRALDGI----LEYVFLGLLKLTQTNFKDTVTP 629
            ||..:|.:...::             |..|...:.::.|    ::.:.||:.::   :.::.:..
Human   511 NFLAENHSYEKII-------------DEICKYQKLIEEIQYTSIKTIRLGMFEM---HCEELIRA 559

  Fly   630 VCSRLQNVLATYLPKL---AEEETTRLYEEAQDFHGRICYEPHETLEIVAHIRFLDKCSTELDGI 691
            :..|...:....|.|:   .:|..|||.:|.:....:....|..|.|::....::.|..     :
Human   560 LVKRADIICGKLLAKMFRDHQEVNTRLCDEFERIAEKALSTPPNTAELMEMKAYIQKVE-----V 619

  Fly   692 FDGIDYVHDLLLIIKDFGIPIDDDSKEDYMDTEDYLN-----------------RTRETLEEIRE 739
            .|.|:....|:            |||.......:|:|                 |..|..||.|:
Human   620 TDMIELEQRLV------------DSKNCLAFLIEYVNFSPADMRLNNSVFQWYGRMGEIFEEHRK 672

  Fly   740 KRQDFINRLEDAMQDDIAALKEDIHEVA-----------IEALQPWLLDANSNRLSVTNKLDSML 793
            ..::.|.:.::.::.......|::...|           ::.:|.:|..|.    .:..|||...
Human   673 IIKEKIEQYQEGLKLRCERFVEELESYAKQSEEFYSFGDLQDVQRYLKKAQ----ILNGKLDLAA 733

  Fly   794 ERLNKCRETADEFLGY-------QKEFQIDLTMYDEMASGFYDIRMRQNLYRTWSDWEESLAEWI 851
            :::.:. ...:|..|:       :|:.|..|..|             ..||.|..::..:...|.
Human   734 DKIEQF-NAEEEAFGWLPSVYPQRKKIQDGLNPY-------------LRLYETAVEFSSNYRAWT 784

  Fly   852 VSDFNTLNVVDMVELN-SKTIKNCMQFQKYLPENNIVPVLQK----SAEAFKEKLPVIGYLRNPN 911
            ...::.:| .|.||.: ....:...:.:|...::.....:.|    ..|.||:.:|:|..:.||.
Human   785 EGPYHKVN-PDQVEADIGNYWRGLYKLEKTFHDSPYALAMTKKVRSKVEDFKQHIPLIQVICNPG 848

  Fly   912 LRARHWAEIEDLLNRKFFQEKDILIQTYEDVHAFDDVAIGEALMQISSQATGEVQLENMLKGIET 976
            ||.|||..:..::........|..:.::.|::....:   :....||..|:.|..||..::.:.|
Human   849 LRPRHWEAMSAIVGYPLQPSDDSTVSSFLDMNLEPYI---DRFEGISEAASKEYSLEKAMEKMIT 910

  Fly   977 TWKETELSIVPHHDAKDVFILAGTEELQAVLDDSNVNINTIAASKFVGPIKSKVDEWINAMDQFA 1041
            .|...|..|..:.:. ..||||..:|:|.:|||..:...|:..|.|:.|.:.::.||...:....
Human   911 EWDAVEFVIHSYRET-GTFILASVDEIQMLLDDHIIKTQTMRGSPFIKPYEKQMREWEGKLLLLQ 974

  Fly  1042 KTFESWMDCQGAWIYLEAIFASADIQRQLPHEAKMFFTVDKSFKETVR---QAKKVALALPTMSS 1103
            :..:.|:..|..|:|||.||:|.||..|:|.|.:.|..|||::::.:|   |.|.|.    |:.:
Human   975 EILDEWLKVQATWLYLEPIFSSPDIMSQMPEEGRRFTAVDKTWRDIMRSVMQDKHVL----TVVT 1035

  Fly  1104 VD-VHKVLVENNRLLDLISRGLEAYLEVKRVVFPRFYFLSNDELLEILAQTRIPQAVQPHLRKCF 1167
            :| :.:.|.::|.||:||.:||..|||.||:.||||:|||||||||||::|:.|..|||||:|||
Human  1036 IDRMLERLKKSNELLELILKGLNEYLEKKRLFFPRFFFLSNDELLEILSETKDPTRVQPHLKKCF 1100

  Fly  1168 DAIYRLEFGSKEGGDGKMVATNDIVAFLSPEGEKLQFGKGL---KARGAVEEWLSKVEEAMFVSC 1229
            :.|.::||          ..|.||....|.|||.::..:.:   ||||.||:||.::|..|..|.
Human  1101 EGIAKVEF----------TETLDITHMKSSEGEVVELIEIISTAKARGQVEKWLVELERVMINSI 1155

  Fly  1230 KRYMRFGYQCYPAKEREDWFQDHPNQVVLTVSQVQWAADIHRIYEGKERNPLNI--LEKMAKFEI 1292
            .:........|...||.:|.:|.|.|.||.|||:.|..::....      |:.|  ||:..|
Human  1156 HKVTGDATFAYTKYERINWVRDWPGQTVLCVSQIFWTKEVQTAI------PMGIKALEQYLK--- 1211

  Fly  1293 KCLKDLGALAALTRKNISSLLRKILCALITIDVHAKDSVRMLIEKEVCKASDFNWLKMLRFYWAD 1357
            .|.:.:..:..|.|..:|...|..|.||:.:||||:|.:..|::|.:...|||.||..||:||.:
Human  1212 TCNRQIDDIVTLVRGKLSMQNRVTLGALVVLDVHARDVLSSLVKKNISDDSDFEWLSQLRYYWQE 1276

  Fly  1358 -ETETVYSRMAAANIPYYYEYLGAGGVLVLTPLTDRCYLCLMGAFQMDLGGAPAGPAGTGKTETT 1421
             ..||   :|..|.:.|.|||||....||:||||||||..|.||..:.|||||.|||||||||||
Human  1277 NHLET---KMINAGLRYGYEYLGNSPRLVITPLTDRCYRTLFGALHLHLGGAPEGPAGTGKTETT 1338

  Fly  1422 KDLAKALAKQCVVFNCSDGLDYKMMGRFFSGLAQCGAWCCFDEFNRIDIEVLSVIAQQLITIRTA 1486
            ||||||:|||||||||||||||..:|:||.||..||||.|||||||||:|||||:|||::||:..
Human  1339 KDLAKAVAKQCVVFNCSDGLDYLALGKFFKGLLSCGAWACFDEFNRIDLEVLSVVAQQILTIQRG 1403

  Fly  1487 KAMRVKRFIFEGREIKINRSCCVFITMNPGYAGRTELPDNLKALFRPISMMVPDYALISEVILYS 1551
            ........:|||.|:|::.:|.||||||||||||:|||||||||||.::|||||||:|:|::|||
Human  1404 INAGADILMFEGTELKLDPTCAVFITMNPGYAGRSELPDNLKALFRTVAMMVPDYAMIAEIVLYS 1468

  Fly  1552 EGFEDPKILARKMVQMYQLCSQQLSQQNHYDFGMRAVKSVLVMAGALKRASPNQREDITLIAALR 1616
            .||...:.|:.|:|..|:|||:|||.|:|||:|||||||||..||.||...||:.|:|.|:.::.
Human  1469 CGFVTARPLSVKIVATYRLCSEQLSSQHHYDYGMRAVKSVLTAAGNLKLKYPNENEEILLLRSII 1533

  Fly  1617 DSNIPKFLADDAVLFRGILSDLFPGVELPDSQHPHLEASLRLGLRQKNLQAVPTTIRKCLQLYET 1681
            |.|:||||:.|..||.||.|||||||:||...:..|.|:::......|||.......|.||:||.
Human  1534 DVNLPKFLSHDLPLFEGITSDLFPGVKLPKPDYNDLLAAIKDNCASMNLQMTAFFSEKILQVYEM 1598

  Fly  1682 MCVRWGVMLVGPTGGGKSVVLHALEFALSHLFENEVQDPNFRPVVIQTMNPKAVTMNELYGYVDL 1746
            |.||.|.|:||...|||:.....|..||:.:.|..:.:.|  .|.|..:|||:|||.:|||..|.
Human  1599 MIVRHGFMIVGEPFGGKTSAYRVLAGALNDICEKGLMEEN--KVQITVLNPKSVTMGQLYGQFDS 1661

  Fly  1747 KTLEWQDGLLGLAVRTATTVEDEIHQWIMCDGPVDAVWIENLNTVLDDNKMLCLANSERIKLTAW 1811
            .:.||.||:|.::.|...:......:|::.|||||||||||:||||||||.|||.:.|.|:::..
Human  1662 VSHEWSDGVLAVSFRAFASSVTPDRKWLIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQ 1726

  Fly  1812 IHMLFEVQDLLQASPATVSRCGMVYVDPGDLGWIPLIDTWREVDMKHKLPAPLAEFCYQLFVGYF 1876
            ::::||..||..|||||||||||:|::|..|||.||:.:|..:     |||.::....:..:|.|
Human  1727 MNLIFEPMDLEVASPATVSRCGMIYMEPHMLGWRPLMLSWVNL-----LPASVSVIQKEFIMGLF 1786

  Fly  1877 DKALKIE--------RKRAVYTIHQVLGSKVRLC-CELNSAQFEAVKWSAMSEEQGKELVTKIFA 1932
            |:.:.:.        ::.:..:...::.|.:.|. |.::....| ||....::.:...|:..||.
Human  1787 DRMVPVSVEFIRKHTKELSPTSDTNLVRSLMNLIDCFMDDFADE-VKLKERNDRETYSLLEGIFL 1850

  Fly  1933 WAVLWAIASNLKDAEKVSF--------------------------EEQWSKAIAQHPNMTLP--- 1968
            ::::|::.::..|.:::.|                          |:..|||      :|:|
Human  1851 FSLIWSVGASCTDDDRLKFNKILRELMESPISDRTRNTFKLQSGTEQTSSKA------LTVPFPE 1909

  Fly  1969 NFTLWNYRIDLEKM-DWGSWIDIMAKFVFDP-ETSYYDMQVPTVDTTKYGYVSDLLFKRGMPVMV 2031
            ..|:::|:...|.: .|..||..:.:....| :..:.::.|||:||.:|..:.:||.....|.:.
Human  1910 KGTIYDYQFVTEGIGKWEPWIKKLKEAPPIPKDVMFNEIIVPTLDTIRYSALMELLTTHQKPSIF 1974

  Fly  2032 TGDTGVGKTVLAIS-CMKRLSQGNVIPVILNFSAQTSSNRTQEMIEGPLEKRKKTQLGAPVGKTV 2095
            .|.||.||:|...: .:.:|::....|:::||||||::.:||.::...|:||:|...|.|:||.:
Human  1975 VGPTGTGKSVYITNFLLNQLNKEIYKPLLINFSAQTTAAQTQNIVMSKLDKRRKGVFGPPLGKRM 2039

  Fly  2096 IVFIDDVNMPKLDTYGASPAIELLRQFLDFKGFYDREKLYWKEILDVVLGCACAPPGGGRNPLTP 2160
            :||:||||||..:.|||.|.||||||:||...:||.:.....:::|:.:.||..||||||||:||
Human  2040 VVFVDDVNMPAREVYGAQPPIELLRQWLDHWNWYDLKDCSMIKLVDIQIMCAMGPPGGGRNPVTP 2104

  Fly  2161 RFVRHFALFSLPKPNEETLTQIFNGILRGFLQ---TFSSAVRALSEPMVNACVDVYMRVATVMLP 2222
            |::|||.:.::.:.:::::..||:.||...|:   .|......|:..:||..:.:|......:||
Human  2105 RYMRHFNIITINEFSDKSMYTIFSRILTWHLEICYKFPDEFLDLTTQIVNGTMTLYKEAMKNLLP 2169

  Fly  2223 TPDKSHYIFNLRDLSKCIQGILQASNLHYNQENQILRLFYHETTRVFHDRLINIEDK----NIFK 2283
            ||.||||:|||||.|:.|||:..:..........|.||:.||..||::|||::..|:    |..:
Human  2170 TPAKSHYLFNLRDFSRVIQGVCLSRPETTETTEVIKRLWVHEVLRVYYDRLLDNTDRSWLINYIQ 2234

  Fly  2284 ALMKEVCMDHFN---RPVINDNEPPILFGD-----FMVFGKPKNERI-YDEIRDHTKLESVLNDY 2339
            .:::....:.|:   :.:..||:..:...|     |..|..||.|.. |.||.|...|..::..:
Human  2235 EILRNYMYEDFHELFQRLDFDNDGMVEADDLRSLMFCDFHDPKREDTNYREIADVDNLRMIVEIH 2299

  Fly  2340 IADYNSVAVGKQMKLILFQDAMEHTVRLARLLRSDRGNGLLVGVAGMGKQSLTRLASHVNEYNCW 2404
            :.:||::: .|.|.|:||:.|:||..|::|:|:..|.:.|||||.|.|:||:||||:|:.:|:.:
Human  2300 LEEYNNIS-KKPMNLVLFRFAIEHISRISRILKQPRSHALLVGVGGSGRQSVTRLAAHMADYSVF 2363

  Fly  2405 QIEMRRNYDLNAFHEDLRVLYRIAGIDNQPVTFLLIDSQIVEEEFLEDINNILNSGEVPNLFEGD 2469
            |:|:.:.||...:||||:|:.|..........||..|:||.||.||||::|:||:||:||||..|
Human  2364 QVEISKGYDTTEWHEDLKVILRKCAEGEMQGVFLFTDTQIKEESFLEDVSNLLNAGEIPNLFALD 2428

  Fly  2470 EFEKIILDARDGCNE----NRKDDPCTRDD-----IYKFFINRVRNNLHVVMSMSPVGDAFRRRC 2525
            |.::|       |::    :|:.|...:.|     ::..||:..|:.||||::|||:|||||.|.
Human  2429 EKQEI-------CDKMRQLDRQRDKTKQTDGSPIALFNMFIDHCRSQLHVVLAMSPIGDAFRNRL 2486

  Fly  2526 RMFPSLVNCTTIDWFTSWPTEALYSVALGLLTKIAPKMEDRISLASTTVFMHKTVEDASVKFYKE 2590
            |.||:||||.|||||.|||.:||.:||...|.:|....|.|..........|.:..|.|..|:.|
Human  2487 RKFPALVNCCTIDWFQSWPEDALQAVASRFLEEIEMSEEIRDGCIDMCKSFHTSTIDLSKSFFVE 2551

  Fly  2591 MKRHYYTTPSSYLELLKLYQNLLKIKNMEIIAKRKRIANGLNKLLETNEVIAVMGKELEVMVPQL 2655
            ::|:.|.||:|||||:..::.||:.|..|::..:||...||.||...:..:|.|..|||.:.|||
Human  2552 LQRYNYVTPTSYLELISTFKLLLEKKRSEVMKMKKRYEVGLEKLDSASSQVATMQMELEALHPQL 2616

  Fly  2656 DEKSAMMKSLVDNLTKETKQADAVKQSVLEDEMNAKEKAAVAQAISEDAGKDLEIAMPALREAEE 2720
            ...|..:..::..:.||:.:....::.|..||..|.|:|..::||.::...||..|:|.|..|..
Human  2617 KVASKEVDEMMIMIEKESVEVAKTEKIVKADETIANEQAMASKAIKDECDADLAGALPILESALA 2681

  Fly  2721 ALKGLTKADINELKSFTTPPALVQFCMEAVCILLGVK------PT---------WASAKAIMADI 2770
            ||..||..||..:||..:|||.|:..|||:|||.|:|      ||         |..||.::.|:
Human  2682 ALDTLTAQDITVVKSMKSPPAGVKLVMEAICILKGIKADKIPDPTGSGKKIEDFWGPAKRLLGDM 2746

  Fly  2771 NFIKRLFEYDKEHMKEDTLKKVKK-YIDHKDFVPAKFEKVSKVAKSMSMWVISMDKFSKVYKVVE 2834
            .|::.|.||||:::....:..::| ||.:.||||.|....|..|:.:..|||:||.:.||.|:|.
Human  2747 RFLQSLHEYDKDNIPPAYMNIIRKNYIPNPDFVPEKIRNASTAAEGLCKWVIAMDSYDKVAKIVA 2811

  Fly  2835 PKIKRKEAAEAELKEVMTVLRQKQKELAAVEAKIQGLRDSLEEKQREFQVIQDNVDLTYGRINRA 2899
            ||..:..|||.|||..|..||:||..|..|:.|:..|:|:||..:::...:::.|||...::.||
Human  2812 PKKIKLAAAEGELKIAMDGLRKKQAALKEVQDKLARLQDTLELNKQKKADLENQVDLCSKKLERA 2876

  Fly  2900 GRLTSALSDEQVRWRETVKSLTGDLACVPGDVLVAAACVAYLGAFSHEYRRDMSALWVSKCREHK 2964
            .:|...|..|:.||..|...|......:.||:|:::..|||||||:..||::.:..|.:.|:...
Human  2877 EQLIGGLGGEKTRWSHTALELGQLYINLTGDILISSGVVAYLGAFTSTYRQNQTKEWTTLCKGRD 2941

  Fly  2965 IPSSPEFNLLKVLGDPYEMRQWNVDGLPKDNISIENGIYATRALRWALMIDPQEQANRWIRNMER 3029
            ||.|.:.:|:..||:...:|.||:.|||.|:.||:|||....|.||.||||||.|||:||:|||:
Human  2942 IPCSDDCSLMGTLGEAVTIRTWNIAGLPSDSFSIDNGIIIMNARRWPLMIDPQSQANKWIKNMEK 3006

  Fly  3030 ANNLQVIKMTDSTMMRVLENAVRQGYPVLLEEINETIDPSLRPILQRETYRFEGRTYLKLGDMVI 3094
            ||:|.|||:::...:|.|||.::.|.|||||.:.|.:||.|.|:|.::|::..|.|.::|||..|
Human  3007 ANSLYVIKLSEPDYVRTLENCIQFGTPVLLENVGEELDPILEPLLLKQTFKQGGSTCIRLGDSTI 3071

  Fly  3095 DYDDNFKLYMTTKLPNPHYLPEVCINVTLVNFLVTESGLEDQLLADIVAIELPAMEIQRNDLVVK 3159
            :|..:|:.|:||||.|||||||..:.|||:||::|..|::||||..:||.|.|.:|.::..|:::
Human  3072 EYAPDFRFYITTKLRNPHYLPETSVKVTLLNFMITPEGMQDQLLGIVVAQERPDLEEEKQALILQ 3136

  Fly  3160 INSDKQQLLALEDKVLKLLFNSEGNILDDEELVETLNDAKETSLIIAARLIDTEETEKVITASRE 3224
            ...:|:||..:|||:|::|.:||||||:||..::.|:.:|..:..|:.:....|||||.|..:|.
Human  3137 GAENKRQLKEIEDKILEVLSSSEGNILEDETAIKILSSSKALANEISQKQEVAEETEKKIDTTRM 3201

  Fly  3225 RYRILASRGAILYFVVAGLAEIDPMYQYSLKYFTQVFCNVLRLDHPPQS--VEVRISTLMTDELR 3287
            .||.:|...:||:|.:|.||.|:|||||||.:|..:|  :|.:::..:|  :..|:..|......
Human  3202 GYRPIAIHSSILFFSLADLANIEPMYQYSLTWFINLF--ILSIENSEKSEILAKRLQILKDHFTY 3264

  Fly  3288 AIFDNISRGLFENHKIIFSFLLALSVERQEGRVTEEEFLFLSRGPVG------NIRTKIQPAKIK 3346
            :::.|:.|.|||..|::|||.|.:::...|..:.:.|:.||..|.:|      |:.|.: |.|
Human  3265 SLYVNVCRSLFEKDKLLFSFCLTINLLLHERAINKAEWRFLLTGGIGLDNPYANLCTWL-PQK-- 3326

  Fly  3347 MSQIEWDSCIFLEDNFSSFFSGLTDELDKPFFIQMQEN-KEVFDFAQTNQPP-TDKWNKRLRVFH 3409
                .||....|:|  ...|..:..|     |:::::. |:|:|..:.:... .::|..:...|.
Human  3327 ----SWDEICRLDD--LPAFKTIRRE-----FMRLKDGWKKVYDSLEPHHEVFPEEWEDKANEFQ 3380

  Fly  3410 KLMFISAFRKPRFLLNVVCYLQSTVGKYFTEASGGTQLSSVYLDTSAVTPLIFVLSTGSDPMSGF 3474
            :::.|...|..:.:..:..::.:.:|:.|.|.. ...|:..:.|::...|||||||.|:|||:..
Human  3381 RMLIIRCLRPDKVIPMLQEFIINRLGRAFIEPP-PFDLAKAFGDSNCCAPLIFVLSPGADPMAAL 3444

  Fly  3475 LKFTTQMQF-TDKYYSISLGQGQGPLAENLIEKSLRLGHWVFLQNCHLATSFMQTLETIVRNLTL 3538
            |||.....: ..|..|:||||||||:|..::||:::.|.||.|||||||||:|.|||.:...|:.
Human  3445 LKFADDQGYGGSKLSSLSLGQGQGPIAMKMLEKAVKEGTWVVLQNCHLATSWMPTLEKVCEELSP 3509

  Fly  3539 GITKAHVDFRLYLSSMPIQTFPISVLQNSVKITNEPPKGIKANVFGA-LTDLKQD--FFEQHIQN 3600
            ..|  |.|||::|:|.|...||:|||||.||:|||.|||::||:..: |.|...|  ||....:.
Human  3510 EST--HPDFRMWLTSYPSPNFPVSVLQNGVKMTNEAPKGLRANIIRSYLMDPISDPEFFGSCKKP 3572

  Fly  3601 GNWRAIVFGLCMFHAVLLERRKFGPLGWNITYEFSESDRECGLKTLDFFIDREVLDEIPWEAILY 3665
            ..::.:::|||.|||::.||||||||||||.|||:|:|....::.|..|:::  .:|:|:||:.|
Human  3573 EEFKKLLYGLCFFHALVQERRKFGPLGWNIPYEFNETDLRISVQQLHMFLNQ--YEELPYEALRY 3635

  Fly  3666 INGDITWGGRVTDYWDLRCLRTILTIFSSKRIIQ-PDYKYCRGDSYYRDPRKKTLTEYSAYVQGF 3729
            :.|:..:||||||.||.|.||:||..|.:..::: .|||:.....|:..| ......|..|.:..
Human  3636 MTGECNYGGRVTDDWDRRTLRSILNKFFNPELVENSDYKFDSSGIYFVPP-SGDHKSYIEYTKTL 3699

  Fly  3730 PVLEDPEIFGMNQNANIVFQTKETAFFINTLLLGQPRSA---ADEGQAMENEIAQQTIARIQK-- 3789
            |:...|||||||.||:|.....||....:.:||.|.|||   |.....:.||:|...:.::..
Human  3700 PLTPAPEIFGMNANADITKDQSETQLLFDNILLTQSRSAGAGAKSSDEVVNEVASDILGKLPNNF 3764

  Fly  3790 ALATKIKREPIHDTLSVLDAKGQVPSLTIVLVQEIDRFNIALGIIHDSLVNLSKAIKGLVVMSEE 3854
            .:...::|.|...|          .|:..|||||:.|||..|..|.||.||:.||||||.|||.:
Human  3765 DIEAAMRRYPTTYT----------QSMNTVLVQEMGRFNKLLKTIRDSCVNIQKAIKGLAVMSTD 3819

  Fly  3855 LENVFKALLSNQVPASWAKRSFLSIKPLPSYISDFQRRIDFIQQWAENGAPRSYWISGFFFPQSF 3919
            ||.|..::|:.::|..|..:|:.|:|||.||::||..|:.|:|||.|.|.|..:|:|||||.|:|
Human  3820 LEEVVSSILNVKIPEMWMGKSYPSLKPLGSYVNDFLARLKFLQQWYEVGPPPVFWLSGFFFTQAF 3884

  Fly  3920 LTGVLQTYARRRVLPIDSLKIDFDVFERELVQQDFFEMHTNNMSDQKLYGNLPECTDAIINVHGI 3984
            |||..|.|||:..:|||.|..|::|.|                  .|.|.:.||  |.:. :||:
Human  3885 LTGAQQNYARKYTIPIDLLGFDYEVME------------------DKEYKHPPE--DGVF-IHGL 3928

  Fly  3985 FIEAARWDLSKGGLCDANFGELFSRMPVVRFKPC--LEISPTVRYEAPLYKTQQRSGVLSTTGHS 4047
            |::.|.|:.....|.:::...|:..:||:..|||  .:|.....|.||||||.:|.|||||||||
Human  3929 FLDGASWNRKIKKLAESHPKILYDTVPVMWLKPCKRADIPKRPSYVAPLYKTSERRGVLSTTGHS 3993

  Fly  4048 TNFILAVLLRSHNDPEFWIMRGTALV 4073
            |||::|:.|.|....|.||.||.||:
Human  3994 TNFVIAMTLPSDQPKEHWIGRGVALL 4019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc16F	NP_523394.1	DHC_N2	829..1234	CDD:285579	132/416 (32%)
		P-loop_NTPase	1373..1603	CDD:304359	154/229 (67%)
		P-loop_NTPase	1687..1832	CDD:304359	66/144 (46%)
		P-loop_NTPase	1994..2264	CDD:304359	103/274 (38%)
		P-loop_NTPase	2343..2613	CDD:304359	119/278 (43%)
		MT	2625..2957	CDD:289543	126/347 (36%)
		AAA_9	2985..3201	CDD:289547	106/215 (49%)
		Dynein_heavy	3342..4066	CDD:281078	284/737 (39%)
DNAH7	NP_061720.2	Stem. /evidence=ECO:0000250	1..1289		338/1509 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..121		17/98 (17%)
		DHC_N2	763..1162	CDD:285579	134/430 (31%)
		P-loop_NTPase	1290..1520	CDD:304359	154/229 (67%)
		AAA 1. /evidence=ECO:0000250	1290..1511		150/220 (68%)
		AAA 2. /evidence=ECO:0000250	1571..1802		96/237 (41%)
		P-loop_NTPase	1604..1747	CDD:304359	66/144 (46%)
		AAA 3. /evidence=ECO:0000250	1938..2189		98/250 (39%)
		P-loop_NTPase	1942..2211	CDD:304359	102/268 (38%)
		AAA 4. /evidence=ECO:0000250	2302..2555		110/260 (42%)
		P-loop_NTPase	2303..2574	CDD:304359	119/278 (43%)
		Stalk. /evidence=ECO:0000250	2572..2873		109/300 (36%)
		MT	2586..2933	CDD:289543	126/346 (36%)
		AAA 5. /evidence=ECO:0000250	2954..3184		110/229 (48%)
		AAA_9	2962..3178	CDD:289547	106/215 (49%)
		Dynein_heavy	3322..4012	CDD:281078	284/740 (38%)
		AAA 6. /evidence=ECO:0000250	3397..3620		103/225 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56321
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000321
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720