Protein Alignment CG15373 and DNAI7

DIOPT Version :9

• Sequence 1: NP_001097013.2
• Gene: CG15373 / 32784
• FlyBaseID: FBgn0030889
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_005253463.1
• Gene: DNAI7 / 55259
• HGNCID: 29599
• Length: 780
• Species: Homo sapiens
• Alignment Length: 1231
• Identity: 202/1231 - (16%)
• Similarity: 358/1231 - (29%)
• Gaps: 575/1231 - (46%)

  Fly     2 LSLP------PK-KKLSKKEKARLEAEQAELMRIEMEKEKLKKLEEARQR-KKLEMEQAK----- 53
            ||||      || ||...|:|...:||:.:|:: |.|:.:||:.||||.: :|.|||:.:
Human    51 LSLPGPGGQGPKAKKSGSKKKKVTKAERLKLLQ-EEEERRLKEEEEARLKYEKEEMERLEIQRIE 114

  Fly    54 ----HRQQQEVAENRQRRSQLKDSMLFFDAVRTAIEAIKDGERHERDWEKFMRCNGLPNAASPSD 114
                ||.:   |::.:||::..:.:...:......|.:|...:....|:.:::|:|.|:.:...:
Human   115 KEKWHRLE---AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQE 176

  Fly   115 LRKYIHQWHTDIAKRHLESRNWLLRTDERTLLTQDAQVPDLTRISLRQQQGRLGDVYAHRIKEVL 179
            :..:|..|                  .|:|..|.:..:                    .:.|.||
Human   177 MNTFISLW------------------KEKTNETFEEVI--------------------EKSKVVL 203

  Fly   180 GILNEL-------------DEMLPFKQKSALIAADLVKLK----TEMRVFLKQHLDEFTYKTMSH 227
            .::.:|             |:.:...|:|.|...:|:.||    ||  :.|||      ..|::
Human   204 NLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATE--ILLKQ------ASTLA- 259

  Fly   228 IERDMEIDRPGVSKHIYSSDVFQSFVWTFSKDAQISLNPKARIGEQSSHNEIDFPTIEMQISLPP 292
                 ::|...:.|.|...:| ..:||     |.:..||:        |..:.|...::...:|.
Human   260 -----DLDSGNMEKVIKDENV-TLYVW-----ANLKKNPR--------HRSVRFSETQIGFEIPR 305

  Fly   293 TVHLQSSALRGLWLNYDHFS----------DYCSSYC------LKHARSANANILRQTKREWRKR 341
            .:.....|:|.|..:|||.|          :|.|:..      :|:...|.:..:.:..::..:.
Human   306 ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERG 370

  Fly   342 KEILQAMLDDCGREIPLSELEQLTQDQHSASSQPPRERTYDVDKLYAEYEDELSKAHR------R 400
            ..::|.      .||.:.|                .:...:|....||.|.|..|..|      .
Human   371 SHLIQE------EEIKVEE----------------EQGDIEVKMSSAEEESEAIKCEREMKVLSE 413

  Fly   401 AIGPEAYGMLETD-----------VNLRKYRIIGGVYCIDFLETPQQDKQLNARSFIRTITSANS 454
            .:......::|..           |:|.::..:||||.:|.||.|.|.|.:.....:..:
Human   414 TVSAAQLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEIL----- 473

  Fly   455 LVHKEYYQTYKPPPPVLPGVRRLPEEIEAEMRM--IEAALDKLALVTLQLPDSVIWFEPPVACRW 517
               ||..|.|..||       ...||.|.|...  ||        |||::.::||:||.||..||
Human   474 ---KEGLQKYTYPP-------ETTEEFETENAFPPIE--------VTLEVHENVIFFEDPVVVRW 520

  Fly   518 ETNVETLEMELADGMKPEVQKPHGEGDGEADGTGAVSGTAAATTATPTEATPLSTHAQPSPLKSS 582
            :          |:|       .|...||
Human   521 D----------AEG-------KHWRTDG------------------------------------- 531

  Fly   583 PRCPARMRSQKSDIGGESRQQVLREINDFDLRAIPSDVDLYGLVKDFVVPRLPQGFCVRLEQSTP 647
                                     |::...:
Human   532 -------------------------ISNVSYK--------------------------------- 538

  Fly   648 VMSTGLRQRKVMFLARQAHIRLGQGKDMADDQLEIPKELQRLQLNSKPGLGAEFLDTEEPAEMFP 712
                                               |||
Human   539 -----------------------------------PKE--------------------------- 541

  Fly   713 PLCFDKLLKFRQMAPRSRGPAHLQGYLFSQLIDDMDRLWRLQLPRDQQEEIIQQISEQLSPTGSR 777
                 :|:.|
Human   542 -----RLVTF------------------------------------------------------- 546

  Fly   778 TSEPGEKEPRETENDGDLAENMQPLSQELVDVLQPATAAAAFAYYTGISFVRDSQLPAEPEPESS 842
                                                                             
Human   547 ----------------------------------------------------------------- 546

  Fly   843 AKRSNSMDSSEDDDDDVDSLVELLEGASTAANTLHDLLGPATNSDNSDSESKQKMSNVAAITQGK 907
                              ||               |..||.|
Human   547 ------------------SL---------------DTFGPVT----------------------- 555

  Fly   908 WSTRDVHDTKFNEDKLSIQFRTGRLGIFGFALNKYSNMPYQTWDLRP-DMKNPGTIIFSFTASLI 971
             ..:|.|                            .|||||:|:||| |:..   ::.:.|....
Human   556 -LIQDAH----------------------------INMPYQSWELRPLDVNK---VLLTVTTVFT 588

  Fly   972 SLDMTITKSGYTVNNFQGGSTQGITDMIGKTLSLSELKATLILSAVDIFPDEDAFCYTEGSCEKN 1036
            .:.:.|.::...:::.:....:.|:.:.|..::.......|..:.::|||...:..|...: .|.
Human   589 EIQIQIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIIN-NKV 652

  Fly  1037 YVMEMHCYACLSTLAQSHNFSWSRWNLLAGSRTAVLLVRE-LIEG-KKVPYYSTLLVTPLKTSII 1099
            .::|:..|..::.|:.:..|.||:||||..|...|..||| |.|. .:.|.::.|:.:..:...:
Human   653 PLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRL 717

  Fly  1100 DCTEVSASFNAVGIPGMEYYADLYQLSQAHAQPGSLEKQRTMNPVLRDNVAKILMAIRPLS 1160
            ...|.|.:|:.......|:::.||.:.:..|...::||.|:.|....::|..:|::.|.||
Human   718 KIKEESEAFSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLS 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15373	NP_001097013.2	Casc1_N	14..267	CDD:406371	57/279 (20%)
		Casc1	287..515	CDD:372076	57/262 (22%)
		Casc1	908..1118	CDD:372076	44/212 (21%)
DNAI7	XP_005253463.1	Casc1_N	98..288	CDD:292549	45/250 (18%)
		Casc1	303..518	CDD:289161	57/259 (22%)
		Casc1	542..>685	CDD:289161	41/351 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4426
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D526857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto90377
orthoMCL	1	0.900	-	-		OOG6_104946
Panther	1	1.100	-	-	LDO	PTHR20929
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5140
SonicParanoid	1	1.000	-	-		X3892
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.930