DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6867 and gldn

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_021323372.1	Gene:	gldn / 572018	ZFINID:	ZDB-GENE-050119-4	Length:	564	Species:	Danio rerio

Alignment Length:	910	Identity:	181/910 - (19%)
Similarity:	263/910 - (28%)	Gaps:	388/910 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KCPGRQSLTLVYIYLGA--LTLILASLSIVFYTHTQDV-ESLSQVEDNY--SSKSFRVQFQAELM 121
            :|.||.|....::....  ||:|..:..::.....:|: ..|.:||...  .|:|..|:|..::.
Zfish    16 QCGGRMSWQFRWMLYSVCILTVINCAGLVLLLVQQRDLWAQLIEVERQMVEISQSSVVEFMTQVN 80

  Fly   122 RSEEELRRLVN---------RIIEEEQELVGSTTASSTTQSRDPLKNERKFTDNLISHTTRPTGK 177
            ..|.|.:...|         |..||.:..||....|....|                 ..:|.|
Zfish    81 EDEAEYQYSRNKRRRQHRGTRPFEEHEGSVGEEVLSDFQYS-----------------FQQPPG- 127

  Fly   178 RMRRDIASSAPASMHADPLIEFFNPNHRKVLEEQDTEIRKRTGQKGAAPGGDEWIYLNTYCRVPE 242
                      |...|                         :|.:|      |..:.:.||..||.
Zfish   128 ----------PVYQH-------------------------KTEEK------DGMMMMMTYSMVPV 151

  Fly   243 KIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGIPGPKGNRGDVGLPGAPGVDGVGHLGP 307
            ||:...|..|:..|         ..||.||||..|:||:.|..|..|..|:||.||..| .| |.
Zfish   152 KILLDICNSTKGVC---------LTGPPGPPGIAGIPGVDGMPGYNGTDGIPGLPGEPG-AH-GK 205

  Fly   308 AGPRGPKGDAGATGRAGLDGRDGVPGEPGLDGVPGRAGADGKNGLPGRDGKDGLHGKDGKDGLSI 372
            .|.|||.|:.|.            |||.|..|.||..|..|:.|.|..|             :.|
Zfish   206 RGKRGPSGEKGE------------PGEKGEPGYPGPPGPPGEQGEPSND-------------VII 245

  Fly   373 TGPKGAQGPPGERGLKGIAGPRGRPGKPGTNGIPGVPGINAWKLQYPNGSSSNDLLIPPSITDIQ 437
            .||.|..||.|.      .||.|.||.||..|                         ||
Zfish   246 EGPPGPMGPSGP------PGPPGPPGPPGPQG-------------------------PP------ 273

  Fly   438 VPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTINVNGVEMASISGQFLRFTNITRHQM 502
                                                                         ||:.
Zfish   274 -------------------------------------------------------------RHRS 277

  Fly   503 AAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQSSATLECLVEAFPEAIRYWERAYD 567
                                                                        .||:
Zfish   278 ------------------------------------------------------------HRAH- 281

  Fly   568 GKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATMVNFEIAPQDPNSETP 632
                          .|.|             |:..|:.:.|                  ||.:|
Zfish   282 --------------LPIG-------------KESVGHLNSV------------------PNDDT- 300

  Fly   633 YVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKTCYLYAV 697
                                                           ||......:...|.:.:|
Zfish   301 -----------------------------------------------LSQKLASWKTNDCVIKSV 318

  Fly   698 GKPVFHKVVNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQYRMNSI------PRRKY 756
            ..|......:..||:|:.|.:...| ||.:|..        .|:.|:....|||      .....
Zfish   319 QNPRHLMKTSSTFGAWMMDTAAHDD-EKIWVAE--------HFSGRLIKEYNSIAAFQNSSSESI 374

  Fly   757 EIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLPYAGVAAANRLY--TTDYNYMD 819
            :::..|.|..|.|.|||.:|....:..:.|.||.:  ||...|........|..|  .....|..
Zfish   375 DVRRFFQGCGHAVHNGSIFYHIAGTSNIAKFDLQT--KILHVLSIENALYHNLSYLLQNSKTYFK 437

  Fly   820 FNVDEVGLWVIYSTYNSNNTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCGNLYAIDSGTDKN 884
            ...||.|:|:::::...::.:||:||.:|..:....|.|....:.|.:||.||.||..|:   |:
Zfish   438 LAADENGMWIVFASNIDDSLMVARLDEKTFSVSTYINTTYPRTKAGSVFIACGILYVTDT---KD 499

  Fly   885 TQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRYNEQRLISDNS 949
            |::.|..||.|.|.::.:|....|....:.:.|||....||.||.....:|.:::     :||::
Zfish   500 TKVTYAFDLLKEKPVSASLDLRAPGGVLSMISYNPRDKHLYIWDSSYVKSYQVQF-----LSDSN 559

Fly 950 949
Zfish 560 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968	19/57 (33%)
		IG_like	442..525	CDD:214653	2/82 (2%)
		IGc2	449..511	CDD:197706	2/61 (3%)
		IG_like	544..612	CDD:214653	7/67 (10%)
		Ig	546..612	CDD:143165	7/65 (11%)
		OLF	694..937	CDD:280371	68/250 (27%)
gldn	XP_021323372.1	Collagen	183..>220	CDD:189968	18/50 (36%)
gldn	XP_021323372.1	OLF	315..552	CDD:308029	68/250 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3718
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23192
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3311
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.990