DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6867 and GLDN

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_861454.2	Gene:	GLDN / 342035	HGNCID:	29514	Length:	551	Species:	Homo sapiens

Alignment Length:	781	Identity:	172/781 - (22%)
Similarity:	241/781 - (30%)	Gaps:	309/781 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 GKRMRRDIA--------SSAPASMHADPLIEFFNPNHRKVLEEQDTEIRKRTGQKG-AAP----G 227
            |:..|.|.|        |.||....|.|             ::..:..|.:....| .||    .
Human    56 GREQREDSALRSFLAELSRAPRGASAPP-------------QDPASSARNKRSHSGEPAPHIRAE 107

  Fly   228 GDEWIYLNTYCRVPEKIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGIPGPKGNRGDVG 292
            ..:.:.:.||..||.:::...|..|:..|         ..||.||||.||..|:||..      |
Human   108 SHDMLMMMTYSMVPIRVMVDLCNSTKGIC---------LTGPSGPPGPPGAGGLPGHN------G 157

  Fly   293 LPGAPGVDGVGHLGPAGPRGPKGDAGATGRAGLDGRDGVPGEPGLDGVPGRAGADGKNGLPGRDG 357
            |.|.|        ||.||:|.||..|..|:.|:.|..|.|||.|..|..|..|..|..|.||:.|
Human   158 LDGQP--------GPQGPKGEKGANGKRGKMGIPGAAGNPGERGEKGDHGELGLQGNEGPPGQKG 214

  Fly   358 KDGLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGRPGKPGTNGIPGVPGINAWKLQYPNGS 422
            :.|..|....|.| :.|.||.|||||.            ||.||..|.||.||
Human   215 EKGDKGDVSNDVL-LAGAKGDQGPPGP------------PGPPGPPGPPGPPG------------ 254

  Fly   423 SSNDLLIPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTINVNGVEMASI 487
                                             |..|.|...|.:           .||
Human   255 ---------------------------------SRRAKGPRQPSM-----------FNG------ 269

  Fly   488 SGQFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQSSATLECLV 552
                         |....||
Human   270 -------------QCPGETC--------------------------------------------- 276

  Fly   553 EAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATM 617
                 ||
Human   277 -----AI---------------------------------------------------------- 278

  Fly   618 VNFEIAPQDPNSETPYVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSILNNFEIQATGNLSY 682
                     ||.:|.....:.|......|::|..:.
Human   279 ---------PNDDTLVGKADEKASEHHSPQAESMIT----------------------------- 305

  Fly   683 PGLPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQYR 747
                         ::|.||....|.|.||:|:|:.:..|| ::.:||.......:.||..:
Human   306 -------------SIGNPVQVLKVTETFGTWIRESANKSD-DRIWVTEHFSGIMVKEFKDQ---- 352

  Fly   748 MNSIPRRKY---EIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLPYAGVAAANR 809
             .|:....|   .:...|||..|||:|.|.||.:..|:.:|:.:.......|.:|..|.......
Human   353 -PSLLNGSYTFIHLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKY 416

  Fly   810 LYTTDYNYMDFNVDEVGLWVIY-STYNSNNTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCGN 873
            |:.....|.:..|||.|||:|| |:.:.::.|||:||..|..:..:.|.|....:.|..||..|.
Human   417 LFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFSVVQHVNTTYPKSKAGNAFIARGI 481

  Fly   874 LYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIR 938
            ||..|:   |:.::.:..||..||.:|.|.......|....:.||.....||||:.|:.:.||::
Human   482 LYVTDT---KDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ 543

  Fly   939 Y 939
            :
Human   544 F 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968	25/57 (44%)
		IG_like	442..525	CDD:214653	9/82 (11%)
		IGc2	449..511	CDD:197706	9/61 (15%)
		IG_like	544..612	CDD:214653	2/67 (3%)
		Ig	546..612	CDD:143165	2/65 (3%)
		OLF	694..937	CDD:280371	74/246 (30%)
GLDN	NP_861454.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..107		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..282		73/361 (20%)
		Collagen	160..217	CDD:189968	26/64 (41%)
		OLF	304..542	CDD:280371	74/288 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3518
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23192
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3311
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.990