Protein Alignment CG6867 and GLDN

DIOPT Version :10

• Sequence 1: NP_573262.2
• Gene: CG6867 / 32782
• FlyBaseID: FBgn0030887
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_861454.2
• Gene: GLDN / 342035
• HGNCID: 29514
• Length: 551
• Species: Homo sapiens
• Alignment Length: 781
• Identity: 172/781 - (22%)
• Similarity: 241/781 - (30%)
• Gaps: 309/781 - (39%)

  Fly   176 GKRMRRDIA--------SSAPASMHADPLIEFFNPNHRKVLEEQDTEIRKRTGQKG-AAP----G 227
            |:..|.|.|        |.||....|.|             ::..:..|.:....| .||    .
Human    56 GREQREDSALRSFLAELSRAPRGASAPP-------------QDPASSARNKRSHSGEPAPHIRAE 107

  Fly   228 GDEWIYLNTYCRVPEKIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGIPGPKGNRGDVG 292
            ..:.:.:.||..||.:::...|..|:..|         ..||.||||.||..|:||..      |
Human   108 SHDMLMMMTYSMVPIRVMVDLCNSTKGIC---------LTGPSGPPGPPGAGGLPGHN------G 157

  Fly   293 LPGAPGVDGVGHLGPAGPRGPKGDAGATGRAGLDGRDGVPGEPGLDGVPGRAGADGKNGLPGRDG 357
            |.|.|        ||.||:|.||..|..|:.|:.|..|.|||.|..|..|..|..|..|.||:.|
Human   158 LDGQP--------GPQGPKGEKGANGKRGKMGIPGAAGNPGERGEKGDHGELGLQGNEGPPGQKG 214

  Fly   358 KDGLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGRPGKPGTNGIPGVPGINAWKLQYPNGS 422
            :.|..|....|.| :.|.||.|||||.            ||.||..|.||.||
Human   215 EKGDKGDVSNDVL-LAGAKGDQGPPGP------------PGPPGPPGPPGPPG------------ 254

  Fly   423 SSNDLLIPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTINVNGVEMASI 487
                                             |..|.|...|.:           .||
Human   255 ---------------------------------SRRAKGPRQPSM-----------FNG------ 269

  Fly   488 SGQFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQSSATLECLV 552
                         |....||
Human   270 -------------QCPGETC--------------------------------------------- 276

  Fly   553 EAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATM 617
                 ||
Human   277 -----AI---------------------------------------------------------- 278

  Fly   618 VNFEIAPQDPNSETPYVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSILNNFEIQATGNLSY 682
                     ||.:|.....:.|......|::|..:.
Human   279 ---------PNDDTLVGKADEKASEHHSPQAESMIT----------------------------- 305

  Fly   683 PGLPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQYR 747
                         ::|.||....|.|.||:|:|:.:..|| ::.:||.......:.||..:
Human   306 -------------SIGNPVQVLKVTETFGTWIRESANKSD-DRIWVTEHFSGIMVKEFKDQ---- 352

  Fly   748 MNSIPRRKY---EIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLPYAGVAAANR 809
             .|:....|   .:...|||..|||:|.|.||.:..|:.:|:.:.......|.:|..|.......
Human   353 -PSLLNGSYTFIHLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKY 416

  Fly   810 LYTTDYNYMDFNVDEVGLWVIY-STYNSNNTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCGN 873
            |:.....|.:..|||.|||:|| |:.:.::.|||:||..|..:..:.|.|....:.|..||..|.
Human   417 LFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFSVVQHVNTTYPKSKAGNAFIARGI 481

  Fly   874 LYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIR 938
            ||..|:   |:.::.:..||..||.:|.|.......|....:.||.....||||:.|:.:.||::
Human   482 LYVTDT---KDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ 543

  Fly   939 Y 939
            :
Human   544 F 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	gly_rich_SclB	<257..>409	CDD:468478	58/151 (38%)
		Ig	436..525	CDD:472250	9/88 (10%)
		Ig strand B	453..457	CDD:409353	0/3 (0%)
		Ig strand C	466..470	CDD:409353	0/3 (0%)
		Ig strand E	490..494	CDD:409353	0/3 (0%)
		Ig strand F	504..509	CDD:409353	2/4 (50%)
		Ig strand G	518..521	CDD:409353	0/2 (0%)
		Ig_3	529..611	CDD:464046	2/81 (2%)
		OLF	694..939	CDD:460482	75/248 (30%)
GLDN	NP_861454.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..107		9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..282		73/361 (20%)
		gly_rich_SclB	<157..>291	CDD:468478	63/346 (18%)
		Collagen	157..212	CDD:460189	26/62 (42%)
		OLF	304..544	CDD:460482	75/290 (26%)