DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6867 and Adgrl3

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_011247763.1	Gene:	Adgrl3 / 319387	MGIID:	2441950	Length:	1586	Species:	Mus musculus

Alignment Length:	424	Identity:	100/424 - (23%)
Similarity:	166/424 - (39%)	Gaps:	107/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 ESYP-----EGFKTTMRLTISNLRKDDFGYYHCVARNELNATMVNFEIAPQDP---NSETPYVGN 636
            ||||     .|....|..:.:..|.||                   :|...||   .:...|:.:
Mouse   105 ESYPIELRCPGTDVIMIESANYGRTDD-------------------KICDSDPAQMENIRCYLPD 150

  Fly   637 NMKVYGQR-PPESECPVC---DQCPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKT---CYL 694
            ..|:..|| ...::|.|.   |..|||    |                  ||..|..:.   |..
Mouse   151 AYKIMSQRCNNRTQCAVVAGPDVFPDP----C------------------PGTYKYLEVQYECVP 193

  Fly   695 YAVGKPVF-------------HKVVNE-KFGSWLRDPSPDSDREKTFVTNENDPY---NLFEFTT 742
            |.|.:.||             |...:: :.|:|.:||...||:   .......||   .|.|:::
Mouse   194 YKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDK---IYYMPWTPYRTDTLTEYSS 255

  Fly   743 RIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDL-TSLKKITTQLPYAGVAA 806
            :..: :...|...|::.....|...||::|:.::.:..:..:||.|| |.:|.     ..|.:|.
Mouse   256 KDDF-IAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKS-----GEAIIAN 314

  Fly   807 ANRLYTTDYNY-----MDFNVDEVGLWVIYSTYNSNNTLV-AKLDAETLKMQYNFNITLDHHQFG 865
            ||...|:.|.:     :|..|||.||||||:|..:|..:| ::|:..||:::..::...|.....
Mouse   315 ANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSAS 379

  Fly   866 EMFIVCGNLYAI------DSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVEL 924
            ..|::||.||.:      |.......:|.|:.:..:.|....::||.|.:.:...|.|||....|
Mouse   380 NAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLL 444

  Fly   925 YSWDKGNALTY------------PIRYNEQRLIS 946
            |.|:..:.:.|            |:.:.:...||
Mouse   445 YVWNNYHVVKYSLDFGPLDSRSGPVHHGQVSYIS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968
		IG_like	442..525	CDD:214653
		IGc2	449..511	CDD:197706
		IG_like	544..612	CDD:214653	9/36 (25%)
		Ig	546..612	CDD:143165	9/36 (25%)
		OLF	694..937	CDD:280371	70/284 (25%)
Adgrl3	XP_011247763.1	Gal_Lectin	111..191	CDD:366935	22/120 (18%)
		OLF	205..461	CDD:128580	66/264 (25%)
		HormR	563..627	CDD:214468
		GAIN	636..856	CDD:374574
		GPS	882..934	CDD:197639
		7tmB2_Latrophilin-3	942..1208	CDD:320671
		TM helix 1	945..969	CDD:320671
		TM helix 2	978..999	CDD:320671
		TM helix 3	1009..1031	CDD:320671
		TM helix 4	1050..1066	CDD:320671
		TM helix 5	1085..1108	CDD:320671
		TM helix 6	1141..1166	CDD:320671
		TM helix 7	1170..1195	CDD:320671
		Latrophilin	1208..1586	CDD:367050
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5381
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810