DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6867 and OLFML2B

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001334629.1	Gene:	OLFML2B / 25903	HGNCID:	24558	Length:	752	Species:	Homo sapiens

Alignment Length:	499	Identity:	131/499 - (26%)
Similarity:	200/499 - (40%)	Gaps:	118/499 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 NGVEMASISGQFLR----FTNITRHQMA-------AYTCFANNGIAPVANATYLVEVQFAPMISV 533
            |||::. |..|.||    .|::||...|       |.|...|...||.::|        .|..|.
Human   327 NGVDLL-IEDQLLRHNGLMTSVTRRPAATRQGHSTAVTSDLNARTAPWSSA--------LPQPST 382

  Fly   534 YRQMIYAEYQSSATLECLVEAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLR 598
            ....|........||: .....|:..|       ..:|.||        |:...||:..|.:  :
Human   383 SDPSIANHASVGPTLQ-TTSVSPDPTR-------ESVLQPS--------PQVPATTVAHTAT--Q 429

  Fly   599 KDDFGYYHCVARNELNATMVNFEIAPQDPNS-ETPYVGNNMKV-YGQRP------PESECPVCDQ 655
            :........|:..|  |.|......|..|.: .|..:|.:... :|..|      ||.|..:.:
Human   430 QPAAPAPPAVSPRE--ALMEAMHTVPVPPTTVRTDSLGKDAPAGWGTTPASPTLSPEEEDDIRN- 491

  Fly   656 CPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRDPSPD 720
                .:.:|||::..     .||          |.|...|  |:       ||  |:|::||.
Human   492 ----VIGRCKDTLST-----ITG----------PTTQNTY--GR-------NE--GAWMKDPL-- 524

  Fly   721 SDREKTFVTNENDPYNLFEFTTRIQYRM----NSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNS 781
            :..|:.:|||......|.||.....::.    ||     |::...:.|..|||:||:|||.:..:
Human   525 AKDERIYVTNYYYGNTLVEFRNLENFKQGRWSNS-----YKLPYSWIGTGHVVYNGAFYYNRAFT 584

  Fly   782 DLVVKLDLTSLKKITTQLPYAGVAAANRLYTTDY-----------NYMDFNVDEVGLWVIYST-- 833
            ..::|.||..          ..|||...|:...|           :.:||.|||.|||:||..
Human   585 RNIIKYDLKQ----------RYVAAWAMLHDVAYEEATPWRWQGHSDVDFAVDENGLWLIYPALD 639

  Fly   834 ---YNSNNTLVAKLDAETLKMQ--YNFNITLDHHQFGEMFIVCGNLYAIDSGTDKNTQIRYVVDL 893
               ::....:::||:|..|..|  ..:...|..:.:|..|::||.|||:||...:|..|.|..|.
Human   640 DEGFSQEVIVLSKLNAADLSTQKETTWRTGLRRNFYGNCFVICGVLYAVDSYNQRNANISYAFDT 704

  Fly   894 YKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPI 937
            :....:...|.|.|.:|:||.:.|||....||:||.|:.:||.:
Human   705 HTNTQIVPRLLFENEYSYTTQIDYNPKDRLLYAWDNGHQVTYHV 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968
		IG_like	442..525	CDD:214653	17/55 (31%)
		IGc2	449..511	CDD:197706	13/41 (32%)
		IG_like	544..612	CDD:214653	12/67 (18%)
		Ig	546..612	CDD:143165	12/65 (18%)
		OLF	694..937	CDD:280371	80/264 (30%)
OLFML2B	NP_001334629.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..439		23/116 (20%)
OLFML2B	NP_001334629.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..486		7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5353
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23192
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910