DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6867 and Gldn

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_796324.1	Gene:	Gldn / 235379	MGIID:	2388361	Length:	549	Species:	Mus musculus

Alignment Length:	782	Identity:	170/782 - (21%)
Similarity:	244/782 - (31%)	Gaps:	314/782 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 GKRMRRDIA--------SSAPASM---HADPLIEFFNPNHRKVLEEQDTEIRKRTGQKGAAPGGD 229
            |:..|.|.|        |.||..:   ..||:..  ..|.|....|..:.||..:         .
Mouse    56 GREQREDSALRAFLAELSRAPGRVPEPSQDPMSA--ARNKRSHNGEPASHIRAES---------Q 109

  Fly   230 EWIYLNTYCRVPEKIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGIPGPKGNRGDVGLP 294
            :.:.:.||..||.:::...|..||..|         ..||.||||.||..|:||..|:.|..||
Mouse   110 DMMMMMTYSMVPIRVMIDLCNSTQGIC---------LTGPPGPPGPPGAGGLPGHNGSDGQPGL- 164

  Fly   295 GAPGVDGVGHLGPAGPRGPKGDAGATGRAGLDGRDGVPGEPGLDGVPGRAGADGKNGLPGRDGKD 359
                         .||:|.||..|..|:.||.|..|.|||.|..|..|..|..|..|.||:.|..
Mouse   165 -------------QGPKGEKGAIGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDK 216

  Fly   360 GLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGRPGKPGTNGIPGVPGINAWKLQYPNGSSS 424
            |..|....|.| :||.||.|||||.      .||.|.||.||:....|           |.
Mouse   217 GDKGDVSNDVL-LTGAKGDQGPPGP------PGPPGPPGPPGSRRSKG-----------PR---- 259

  Fly   425 NDLLIPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTINVNGVEMASISG 489
                 ||::.:.|.|                                  |.|
Mouse   260 -----PPNVFNSQCP----------------------------------GET------------- 272

  Fly   490 QFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQSSATLECLVEA 554
                                                                        |::
Mouse   273 ------------------------------------------------------------CVI-- 275

  Fly   555 FPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATMVN 619

Mouse   276 ----------------------------------------------------------------- 275

  Fly   620 FEIAPQDPNSETPYVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSILNNFEIQATGNLSYPG 684
                   ||.:|.....:.|...:..|::|..:.
Mouse   276 -------PNDDTLVGRADEKANERHSPQTESMIT------------------------------- 302

  Fly   685 LPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQYRMN 749
                       ::|.|.....|.|.||:|:|:.:..|| ::.:||.......:.||.. :...:|
Mouse   303 -----------SIGNPAQVLKVRETFGTWMRESANKSD-DRIWVTEHFSGIMVKEFKD-LPALLN 354

  Fly   750 S------IPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLPYAGVAAAN 808
            |      :|..       |||..|.|:|.|.||.:..|:.:|:.:.......|.:|..|......
Mouse   355 SSFTLLHLPHY-------FHGCGHAVYNNSLYYHKGGSNTIVRFEFGKETPQTLKLENALYFDRK 412

  Fly   809 RLYTTDYNYMDFNVDEVGLWVIY-STYNSNNTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCG 872
            .|:.....|.:..|||.|:|:|| |:.:.::.|||:||..|..:..:.|.|....:.|..||..|
Mouse   413 YLFANSKTYFNIAVDEKGIWIIYASSVDGSSILVAQLDERTFSVTQHINTTYPKSKAGNAFIARG 477

  Fly   873 NLYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPI 937
            .||..|:   |:|::.:..||..||.:|.|..|....|....:.||.....||||:.|:.:.||:
Mouse   478 ILYVTDT---KDTRVTFAFDLLGGKQINANFDFRMSQSVLAMLSYNMRDQHLYSWEDGHLMLYPV 539

  Fly   938 RY 939
            ::
Mouse   540 QF 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968	24/57 (42%)
		IG_like	442..525	CDD:214653	2/82 (2%)
		IGc2	449..511	CDD:197706	2/61 (3%)
		IG_like	544..612	CDD:214653	1/67 (1%)
		Ig	546..612	CDD:143165	1/65 (2%)
		OLF	694..937	CDD:280371	74/249 (30%)
Gldn	NP_796324.1	DUF3348	22..>90	CDD:288661	9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..107		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..278		68/362 (19%)
		Collagen	160..217	CDD:189968	26/70 (37%)
		OLF	301..539	CDD:280371	74/291 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44317
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23192
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3311
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940