DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6867 and ADGRL3

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_016863418.1	Gene:	ADGRL3 / 23284	HGNCID:	20974	Length:	1586	Species:	Homo sapiens

Alignment Length:	476	Identity:	110/476 - (23%)
Similarity:	181/476 - (38%)	Gaps:	130/476 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 ANNGI-APVANATYLVEVQFA----PMISVYRQMIYAEYQSSATLECLVEAFPEAIRYWERAYDG 568
            |..|: .|.|....:....|:    ||..|.|:           |.|  |::|..:|
Human    69 ATRGVRGPGAQGAQIAAQAFSRAPIPMAVVRRE-----------LSC--ESYPIELR-------- 112

  Fly   569 KILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATMVNFEIAPQDP---NSE 630
              ...:|...|||...|            |.||                   :|...||   .:.
Human   113 --CPGTDVIMIESANYG------------RTDD-------------------KICDSDPAQMENI 144

  Fly   631 TPYVGNNMKVYGQR-PPESECPVC---DQCPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKT 691
            ..|:.:..|:..|| ...::|.|.   |..|||    |                  ||..|..:.
Human   145 RCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDP----C------------------PGTYKYLEV 187

  Fly   692 ---CYLYAVGKPVF-------------HKVVNE-KFGSWLRDPSPDSDREKTFVTNENDPY---N 736
               |..|.|.:.||             |...:: :.|:|.:||...||:   .......||   .
Human   188 QYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDK---IYYMPWTPYRTDT 249

  Fly   737 LFEFTTRIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDL-TSLKKITTQLP 800
            |.|::::..: :...|...|::.....|...||::|:.::.:..:..:||.|| |.:|.     .
Human   250 LTEYSSKDDF-IAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKS-----G 308

  Fly   801 YAGVAAANRLYTTDYNY-----MDFNVDEVGLWVIYSTYNSNNTLV-AKLDAETLKMQYNFNITL 859
            .|.:|.||...|:.|.:     :|..|||.||||||:|..:|..:| ::|:..||:::..::...
Human   309 EAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAY 373

  Fly   860 DHHQFGEMFIVCGNLYAI------DSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYN 918
            |.......|::||.||.:      |.......:|.|:.:..:.|....::||.|.:.:...|.||
Human   374 DKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYN 438

  Fly   919 PLTVELYSWDKGNALTYPIRY 939
            |....||.|:..:.:.|.:.:
Human   439 PRDNLLYVWNNYHVVKYSLDF 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968
		IG_like	442..525	CDD:214653	4/16 (25%)
		IGc2	449..511	CDD:197706	1/1 (100%)
		IG_like	544..612	CDD:214653	13/67 (19%)
		Ig	546..612	CDD:143165	13/65 (20%)
		OLF	694..937	CDD:280371	70/272 (26%)
ADGRL3	XP_016863418.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5353
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810