DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6867 and ADGRL2

DIOPT Version :9

Sequence 1:NP_573262.2 Gene:CG6867 / 32782 FlyBaseID:FBgn0030887 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_001352934.1 Gene:ADGRL2 / 23266 HGNCID:18582 Length:1469 Species:Homo sapiens


Alignment Length:404 Identity:98/404 - (24%)
Similarity:167/404 - (41%) Gaps:98/404 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   584 EGFKTTMRLTISNL---------RKDDFGYYHCVARNELNATMVNFEIAPQDP----NSETPYVG 635
            ||:...:|...|::         |.||                   :|...||    |::. |:.
Human    43 EGYSIDLRCPGSDVIMIESANYGRTDD-------------------KICDADPFQMENTDC-YLP 87

  Fly   636 NNMKVYGQR-PPESECPVC-------DQCPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKTC 692
            :..|:..|| ...::|.|.       |.||....|         .|:|      |..:|...:..
Human    88 DAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKY---------LEVQ------YECVPYMEQKV 137

  Fly   693 YL------YAVGKPVFHKVVNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQYR---- 747
            ::      ..|..|..:: ..:|.|:|.:||...:|  |.:..    |:..:...|.|:|.    
Human   138 FVCPGTLKAIVDSPCIYE-AEQKAGAWCKDPLQAAD--KIYFM----PWTPYRTDTLIEYASLED 195

  Fly   748 -MNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDL-TSLKKITTQLPYAGVAAANRL 810
             .||.....|::.....|...||::|:.::.:..:..:||.|| |.:|.....:.|     ||..
Human   196 FQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINY-----ANYH 255

  Fly   811 YTTDYNY-----MDFNVDEVGLWVIYSTYNSNNTLV-AKLDAETLKMQYNFNITLDHHQFGEMFI 869
            .|:.|.:     :|..|||.||||||:|..:|..:| ::|:..||:.:..:....|.......|:
Human   256 DTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFM 320

  Fly   870 VCGNLYAI-------DSGTDKNTQIRYVVD--LYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELY 925
            :||.||.:       :|.|.||: |.|:.:  |.:|:.:  ::||.|.:.:...|.|||...:||
Human   321 ICGVLYVVRSVYQDNESETGKNS-IDYIYNTRLNRGEYV--DVPFPNQYQYIAAVDYNPRDNQLY 382

  Fly   926 SWDKGNALTYPIRY 939
            .|:....|.|.:.:
Human   383 VWNNNFILRYSLEF 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6867NP_573262.2 Collagen 306..364 CDD:189968
IG_like 442..525 CDD:214653
IGc2 449..511 CDD:197706
IG_like 544..612 CDD:214653 7/36 (19%)
Ig 546..612 CDD:143165 7/36 (19%)
OLF 694..937 CDD:280371 73/269 (27%)
ADGRL2NP_001352934.1 Gal_Lectin 49..129 CDD:307994 22/114 (19%)
OLF 142..398 CDD:321983 73/270 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..460
HormR 469..533 CDD:214468
GAIN 542..764 CDD:318649
GPS 788..840 CDD:197639
7tmB2_Latrophilin-2 848..1105 CDD:320672
TM helix 1 850..875 CDD:320672
TM helix 2 884..906 CDD:320672
TM helix 3 915..942 CDD:320672
TM helix 4 954..974 CDD:320672
TM helix 5 991..1020 CDD:320672
TM helix 6 1036..1063 CDD:320672
TM helix 7 1067..1092 CDD:320672
Latrophilin 1104..1469 CDD:308136
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1368..1410
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 127 1.000 Domainoid score I5353
eggNOG 1 0.900 - - E1_KOG3545
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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