DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6867 and cof-2

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_491804.2	Gene:	cof-2 / 183582	WormBaseID:	WBGene00000583	Length:	486	Species:	Caenorhabditis elegans

Alignment Length:	595	Identity:	125/595 - (21%)
Similarity:	194/595 - (32%)	Gaps:	219/595 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 KDGLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGR------PGKPGTNGIPGVPGINAWKL 416
            :|.:.||        .||.|..||||:   .|.|||:||      ||.||..|.||..|.:|...
Worm    87 QDDVRGK--------PGPVGPVGPPGK---SGPAGPQGRRGLMGIPGHPGPVGPPGNIGKDADCS 140

  Fly   417 QYPNGSSSNDLLIP-----PSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRT 476
            ..|   ..::||:.     |:|.:::.|              |.....| ||.|.|
Worm   141 SCP---IRDELLMEREFKCPTIENLECP--------------NREAIPT-TPWPSV--------- 178

  Fly   477 INVNGVEMASISGQFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMI--Y 539
                                  .||                           ||..:.:|::  |
Worm   179 ----------------------THQ---------------------------PMPGLVQQILSNY 194

  Fly   540 AEYQSSATLECLVEAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGY 604
            :|.:.     |                                       :::.:.|...|:
Worm   195 SEVEG-----C---------------------------------------VKICLKNYTLDE--- 212

  Fly   605 YHCVARNELNATMVNFEIAPQDPNSETPYVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSIL 669
                   |:..|:..                                       |..|
Worm   213 -------EIEETITT---------------------------------------PVAY------- 224

  Fly   670 NNFEIQATGNLSYPGLPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRD--PSPDSDREKTFVTNEN 732
                ||..           ...|.|..|||||||......:|||:||  |....|..|.:|.|..
Worm   225 ----IQGV-----------TAHCRLQNVGKPVFHSHSTTYYGSWMRDAYPPTGDDARKRYVMNHF 274

  Fly   733 DPYNLFEFTTRIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITT 797
            ..:.|.||....:.|.:.: .:.:.:...|.|..||:||.|.:||:....::.|.:..|.:....
Worm   275 QGHELIEFRNEAEMRRDHV-GKVHRLPYIFDGTNHVIFNASLFYQRAGYPIIAKYEFNSKQYSQF 338

  Fly   798 QLPYAGVAAANRLYTTDYNYMDFNVDEVGLWVIYSTYNSNNTLVAKLDAETLKMQYNFNI-TLDH 861
            ::|.|.......||....||.|..:||..|||::.........|||:|...|.:...||: |::|
Worm   339 EIPGAAYRGDQYLYNNSMNYFDLAIDENALWVMFHYQEEAFLSVAKVDINNLTIYEAFNLTTVNH 403

  Fly   862 HQFGEMFIVCGNLYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYS 926
            .......:|||.:|.::|.::::|.|....|.|:.......:.:.|.:.:...:.||.....:|.
Worm   404 TDVANGIVVCGTIYLVESASEQSTYISTAYDFYRNTYSQPLIKWINLYKNANMISYNAYDKRIYI 468

  Fly   927 WDKGNALTYP 936
            :|.|..|:.|
Worm   469 YDHGYMLSVP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968	1/5 (20%)
		IG_like	442..525	CDD:214653	8/82 (10%)
		IGc2	449..511	CDD:197706	8/61 (13%)
		IG_like	544..612	CDD:214653	3/67 (4%)
		Ig	546..612	CDD:143165	3/65 (5%)
		OLF	694..937	CDD:280371	71/246 (29%)
cof-2	NP_491804.2	OLF	234..478	CDD:366968	70/244 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I3308
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I2654
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010002
OrthoInspector	1	1.000	-	-		otm14138
orthoMCL	1	0.900	-	-		OOG6_112827
Panther	1	1.100	-	-	LDO	PTHR23192
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3311
SonicParanoid	1	1.000	-	-		X205
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890