DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6867 and unc-122

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001309456.1	Gene:	unc-122 / 173359	WormBaseID:	WBGene00006845	Length:	568	Species:	Caenorhabditis elegans

Alignment Length:	746	Identity:	159/746 - (21%)
Similarity:	250/746 - (33%)	Gaps:	272/746 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 KRTGQKGAAPGGDEWIYLNTYCRVPEKIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGI 281
            ||..:|......|..|.:.....:|..::...|.....||....|               .|.|.
Worm    66 KRENKKMPVDLEDYTIIIGQDTIIPRNVLDRSCSQVHQYCSEKSQ---------------RLTGF 115

  Fly   282 PGPKGNRGDVGLPGAPGVDGVGHLGPAGPRGPKGDAGATGRAGLDGRDGVPGEPGLDGVPGRAGA 346
            ||.:|:.||              .||.||.|.:|..|..|..||.|..|:.|||         |.
Worm   116 PGVRGSPGD--------------QGPVGPPGRRGPMGIVGPIGLVGEHGILGEP---------GR 157

  Fly   347 DGKNGLPGRDGKDGLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGRPGKPGTNGIPGVPGI 411
            |||...|..|    |:               .|..|                      |||.|.|
Worm   158 DGKCNCPFPD----LY---------------VQRVP----------------------IPGPPVI 181

  Fly   412 NAWKLQYPNGSSSNDLLIPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRT 476
               |::        :.::|       ||    .|:|:|   :.::......|||.
Worm   182 ---KIE--------EKMVP-------VP----VVVVKE---IEVTKFVPFEPTPP---------- 211

  Fly   477 INVNGVEMASISGQFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAE 541
                                               |..|...        :||
Worm   212 -----------------------------------GFGPPDG--------WAP------------ 221

  Fly   542 YQSSATLECLVEAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYH 606
                        ..|:               |.....:..|     :|:|...:..||......|
Worm   222 ------------GMPK---------------PGRTRKLPRY-----STVRPPPTPKRKTTQSPIH 254

  Fly   607 CVARNELNATMVNFEIAPQDPNSETPYVGNNMKVYGQRPPESECPVCDQCPDPSLYQCKDSILNN 671
             |...|.|.||.::. |..:.::..||:|         ||
Worm   255 -VVPTEKNITMDDWN-AEMNISTPKPYMG---------PP------------------------- 283

  Fly   672 FEIQATGNLSYPGLPKRPKTCYLYAVGKPVFH-KVVNEKFGSWLRDPSPDSDR--EKTFVTNEND 733
                   .|.|     ..|.|.|.|||.||.| :....:.|||:||..|:|.:  ::.:||:...
Worm   284 -------TLGY-----NRKECILAAVGIPVLHAESQYGRVGSWMRDALPNSMKTAKRRWVTDGFA 336

  Fly   734 PYNLFEFTTRIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQ 798
            ...|:|:....|. ::.:.:.||.:.....|..:||:|||:||.:..:..:|:.:|.:..::..:
Worm   337 SPVLYEYEDERQL-LDKVQKIKYYVDYLASGTGNVVYNGSYYYHKHGTTSLVRYELETGVQVEAE 400

  Fly   799 L---------------PYAGVAAANR---LYTTDYNYMDFNVDEVGLWVIYSTYNSNNTLVAKLD 845
            |               .:....|.:|   ||...:||:||.|||.|||.||:..:|....:||::
Worm   401 LDPEMSHIDCGRLPDHTFEECNATDRHVWLYDRPHNYVDFAVDENGLWAIYAGADSETMRMAKIE 465

  Fly   846 AETLKMQYNFNITLDHHQFGEMFIVCGNLYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFS 910
            .....:.. :|:.::..:..:.||:||..|.:.|..:..|||.:..||::...:...:.:.||:.
Worm   466 PSLFVVNI-WNVEVNTTEIADSFIMCGVWYGLKSANNLQTQITHAYDLFRNDTIPGQVEWYNPYQ 529

  Fly   911 HTTTVGYNPLTVELYSWDKGNALTYPIRYNE 941
            ..|.:.||||...||.:|..:.|:..:|..|
Worm   530 GLTMLHYNPLDARLYFFDNSSLLSVNVRIEE 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968	22/57 (39%)
		IG_like	442..525	CDD:214653	8/82 (10%)
		IGc2	449..511	CDD:197706	4/61 (7%)
		IG_like	544..612	CDD:214653	9/67 (13%)
		Ig	546..612	CDD:143165	9/65 (14%)
		OLF	694..937	CDD:280371	74/263 (28%)
unc-122	NP_001309456.1	Collagen	112..161	CDD:189968	25/71 (35%)
unc-122	NP_001309456.1	OLF	294..556	CDD:366968	74/263 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010002
OrthoInspector	1	1.000	-	-		otm14138
orthoMCL	1	0.900	-	-		OOG6_112827
Panther	1	1.100	-	-	O	PTHR23192
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3311
SonicParanoid	1	1.000	-	-		X205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770