DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6867 and olfml2a

DIOPT Version :9

Sequence 1:	NP_573262.2	Gene:	CG6867 / 32782	FlyBaseID:	FBgn0030887	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001096445.1	Gene:	olfml2a / 100125057	XenbaseID:	XB-GENE-996424	Length:	642	Species:	Xenopus tropicalis

Alignment Length:	645	Identity:	138/645 - (21%)
Similarity:	228/645 - (35%)	Gaps:	205/645 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 DIQVPDFQRTVIVEEGRSLNLSCTA-TGTPTP-QVEWRRE-------------------DGRTIN 478
            :::|.|:.....|..|.....|||| ..:..| :.||:.|                   :|...:
Frog    61 NMRVEDYYTVETVSSGSDCKCSCTAPPSSLNPCENEWKMEKMKKQAPELFKLQSMVDLLEGTLYS 125

  Fly   479 VNGVEMASISGQFLR---------FTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVY 534
            ::.:::.|...:.:.         .||:||.     ..|....:..::|.....|.....|:|:.
Frog   126 MDLMKVHSYINKVVSQMNTLEETIKTNLTRE-----NDFMKESVVNLSNQMKKYENYSEIMLSIK 185

  Fly   535 RQMIYAEYQSSATLECLVEAFPEAIRYWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRK 599
            :::....||      .|.:..||          .|..|.:...|:..:|...|.....::|.:.|
Frog   186 KEISNLGYQ------LLQKDAPE----------NKAQDTAGVKGLAKFPNNKKNEGDKSLSKVTK 234

  Fly   600 DDFGYYHCVARNELNATMVNFEIAPQDPNSETP--YVGNNMKVYGQRPPESECPVCDQCPDP--- 659
            |                        :.|.:|.|  .|....:|..|..|....||.    .|
Frog   235 D------------------------KPPKAEKPKKEVSKTKQVPPQPTPRPRSPVL----QPVVI 271

  Fly   660 ---SLYQC------------KDSILN------NFEIQATGNLSYPGLPKRPK------------- 690
               :.|:.            ::|::.      ..||:..||::.|.|.:..:
Frog   272 RGVTYYKAGRQEDAENAAGNRESVVKGPHRGAKQEIRTEGNITEPYLIREERIVATQRATPTPTP 336

  Fly   691 -----------------------TCY---------------------------LYAVGKPVFHKV 705
                                   |.|                           :.:|.:|.....
Frog   337 TTTPTTTQSTTTTTTTRTTISTATEYPLTTLSSTVLGAEAETNKVREGECEGTIASVEQPKKQHS 401

  Fly   706 VNEKFGSWLRDPSPDSDREKTFVTNENDPYNLFEFTTRIQY---RMNSIPRRKYEIQEGFHGNAH 767
            .....|:|::||.....|  .:|||.....||.||.....:   |.:::    |::...:.|..|
Frog   402 YGRNEGAWMKDPIAKDGR--IYVTNYYYGNNLVEFRNLDNFKQGRWSNL----YKVPYNWIGTGH 460

  Fly   768 VVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLPYAGVAAANRLY------TTDYNY-----MDFN 821
            |||.|:|||.:..:..::|.||..          ..|||...|:      ||.:.:     :||.
Frog   461 VVFQGAFYYNRAFTKNIIKYDLKQ----------RFVAAWTLLHDVVYEDTTPWKWRGHSDIDFA 515

  Fly   822 VDEVGLWVIYST----YNSNNTLV-AKLDAE--TLKMQYNFNITLDHHQFGEMFIVCGNLYAIDS 879
            |||.||||||.:    |:....:| :|||..  ::|.:..:...|..:.:|..||:||.|||:|.
Frog   516 VDESGLWVIYPSVDYDYSQQEVIVISKLDPNDLSIKKETTWKTGLKRNSYGNCFIICGILYAVDV 580

  Fly   880 GTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRY 939
            ...|...|.|..|.:.....:..|||.|.::.||.:.|||....||:||.|:.|||.:.:
Frog   581 YNQKEGMISYAYDTHTDTEADPKLPFINEYAFTTQIDYNPKEKVLYAWDNGHQLTYKVNF 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6867	NP_573262.2	Collagen	306..364	CDD:189968
		IG_like	442..525	CDD:214653	18/112 (16%)
		IGc2	449..511	CDD:197706	16/91 (18%)
		IG_like	544..612	CDD:214653	11/67 (16%)
		Ig	546..612	CDD:143165	11/65 (17%)
		OLF	694..937	CDD:280371	82/263 (31%)
olfml2a	NP_001096445.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..265		13/77 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..304		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..353		0/22 (0%)
		OLF	390..638	CDD:280371	82/263 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5174
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23192
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010