DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcnc4

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_006502538.1	Gene:	Kcnc4 / 99738	MGIID:	96670	Length:	666	Species:	Mus musculus

Alignment Length:	654	Identity:	206/654 - (31%)
Similarity:	304/654 - (46%)	Gaps:	154/654 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDT---LLGDPARRLRYFDPLRN-------------------E 139
            |:::|||.|.|.||...||...|.|   .|.||....|   |..:                   |
Mouse    36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGR---PESDGGGAGSSGSSGGGGGGGGCE 97

  Fly   140 YFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYEL------------------GDQA 186
            :||||....|..:|.||:: |:|..|.:|...:|.||:.|:.:                  .::|
Mouse    98 FFFDRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEA 161

  Fly   187 INKFREDEG---------FIKEEERPLPDNEK-------------------QRKVWLLFEYPESS 223
            ::.|...:|         ...::||.|.....                   |.::|.|||.|.||
Mouse   162 LDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSS 226

  Fly   224 QAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFF-------- 280
            :||||||..|:|.||:||..|||||      ::.||...|.|:|.  .|.:||...|
Mouse   227 RAARVVAFASLFFILVSITTFCLET------HEAFNIDRNVTEIH--RVGNITSVRFRREVETEP 283

  Fly   281 ---LIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPK 342
               .||.:|::|||.|..||.:.||:.|:|.::::|:||.:||:|:::
Mouse   284 ILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYL----------------- 331

  Fly   343 APVSPQDKSSNQAMS-LAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIG 406
             .|.....||..|.. |..|||:|.||:.|||||:||..||::||.||:||..|..|||.||.:|
Mouse   332 -EVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 395

  Fly   407 VVLFSSAVYFAE---------AGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLC 462
            |::|::.:|:||         .|:|.:.||:||.|||||||||||:|||||.|....|.:||:||
Mouse   396 VLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALC 460

  Fly   463 AIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSD 527
            |:|||||||:||||||:||..:|.....::::..:...||...|.|...:  :.|....|...|.
Mouse   461 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPI--YCKSEETSPRDST 523

  Fly   528 MMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQ 592
            ..|     .|.|...|      .|.....|..:|.....:.||......|..||      .|...
Mouse   524 YSD-----TSPPAREE------GVVERKRADSKQNGDANAVLSDEEGAGLTQPL------ALAPT 571

  Fly   593 QQQQQQQQQNGFKQQQQQT----------------QQQLQQQQSHTINASAAAATSGSGSSGLTM 641
            .::::..:::|.:.:.::.                ..:...::|.::|..|.||.:..|.|.|..
Mouse   572 PEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVRKGCEKSRSLNNIAGAAGTSLGLSPLAS 636

  Fly   642 RHNN 645
            |:::
Mouse   637 RYSS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	33/127 (26%)
		BTB	99..182	CDD:197585	33/104 (32%)
		Ion_trans	274..488	CDD:278921	105/234 (45%)
		Ion_trans_2	403..479	CDD:285168	48/84 (57%)
Kcnc4	XP_006502538.1	Potassium_chann	1..29	CDD:314363
		BTB_KCNC2_4	35..162	CDD:349722	34/129 (26%)
		Ion_trans	229..487	CDD:366146	127/283 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810