DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcnb2

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001091998.1 Gene:Kcnb2 / 98741 MGIID:99632 Length:907 Species:Mus musculus


Alignment Length:595 Identity:193/595 - (32%)
Similarity:305/595 - (51%) Gaps:105/595 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLR-------------YFDPLRNEYFFDRSRPSF 149
            ||.|||.||..|...|||::.|.|.||    :||             .::...|||||||...:|
Mouse    36 RVKINVGGLNHEVLWRTLDRLPRTRLG----KLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96

  Fly   150 DAILYYYQSGGRLRRPVNVPLDVFSEEI----------------KFYELGDQAINKFREDEGFIK 198
            .:||.:|:: |:|.....:....|.:|:                ::::..:|...:.|.:...::
Mouse    97 TSILNFYRT-GKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMR 160

  Fly   199 EEERPLPDN----EKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFN 259
            |.|....||    ||::|:|.|.|.|.||.||:::||:|:..|:||.:...|.||||.:....|.
Mouse   161 EREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQENDEFG 225

  Fly   260 TTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYF 324
            ..::..|:..            :|.:||.|||.|..:|||:.|||..|.:..:||||::||:||:
Mouse   226 QPSDNRKLAH------------VEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYY 278

  Fly   325 ITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSL-AILRVIRLVRVFRIFKLSRHSKGLQILGRT 388
            :|:.                ::..:||..|..:: .::::.|::|:.||.||:|||.|||.||.|
Mouse   279 VTIF----------------LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFT 327

  Fly   389 LKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGV 453
            |:.|..||||||.||.:|:::|||.|:|||...|::.|.|||..||||.:|||||||||:.|..:
Mouse   328 LRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTL 392

  Fly   454 WGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE---------EMQSQNFNHVTSCPYLP 509
            .|||||.||.|||||.||||:|:||:||:.||..:..||         |...:|.:.|:.  .|.
Mouse   393 LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSM--NLK 455

  Fly   510 GTLGQHM-------KKSSLSESSSDMMDLDDGVE------STPGLTETHPGRSAVAPFLGAQQQQ 561
            ....:.|       :|:..|.::.|.:| |:.:.      :...|:||...:|....:....|..
Mouse   456 DAFARSMELIDVAVEKAGESANTKDSVD-DNHLSPSRWKWARKALSETSSNKSYENKYQEVSQND 519

  Fly   562 QQPVASSLSMSID-----KQLQHPLQQLTQTQLYQQQQ---QQQQQQQNGFKQQQQQ-----TQQ 613
            .....::.|.|..     ::|:....::|:||.:....   |:|.::...::::.:.     .|:
Mouse   520 SHEHLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEQPERPCVYEEEIEMEEVICPQE 584

  Fly   614 QLQQQQSHTI 623
            ||...|:..|
Mouse   585 QLAVAQTEVI 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 32/116 (28%)
BTB 99..182 CDD:197585 31/111 (28%)
Ion_trans 274..488 CDD:278921 101/214 (47%)
Ion_trans_2 403..479 CDD:285168 46/75 (61%)
Kcnb2NP_001091998.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
BTB 37..143 CDD:197585 31/110 (28%)
BTB_2 37..136 CDD:280393 31/103 (30%)
Ion_trans 230..428 CDD:278921 102/225 (45%)
Ion_trans_2 341..422 CDD:285168 50/80 (63%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 4/4 (100%)
Kv2channel 471..755 CDD:281514 23/125 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..742
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..859
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..907
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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