Protein Alignment Sh and KCNK6

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_004814.1
• Gene: KCNK6 / 9424
• HGNCID: 6281
• Length: 313
• Species: Homo sapiens
• Alignment Length: 227
• Identity: 41/227 - (18%)
• Similarity: 69/227 - (30%)
• Gaps: 108/227 - (47%)

  Fly   389 LKASMRELGLLI-----------------------FFLFIGVVL----FSSAVYFAEAGSENSFF 426
            |.||.:.|.||:                       ....:|||:    ...||.||......||.
Human   138 LTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFL 202

  Fly   427 KSIPDAFWWAVVTMTTVGYGDMTPVGVWG-------KIVGSLCAIAGVLTIALPVPVIVSNFNYF 484
                |||::..::::|:|.||..|....|       |::.::....|::.:.|.:
Human   203 ----DAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVL---------- 253

  Fly   485 YHRETDQEEMQSQNFNHVTS-------------CPYLPGTLGQHMKKSSLSESSSDMMDLDDGVE 536
                        |.|.||:.             ||            :|.:....|.:|:
Human   254 ------------QTFRHVSDLHGLTELILLPPPCP------------ASFNADEDDRVDI----- 289

  Fly   537 STPGLTETHPGRSAVAPFLGAQQQQQQPVASS 568
                              ||.|.:..|.:::|
Human   290 ------------------LGPQPESHQQLSAS 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885
		Ion_trans	226..488	CDD:459842	27/132 (20%)
KCNK6	NP_004814.1	Ion_trans_2	75..146	CDD:462301	3/7 (43%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111
		Ion_trans_2	180..256	CDD:462301	20/101 (20%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		2/4 (50%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290		2/30 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..313		6/39 (15%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312