DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and KCNB2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_004761.2	Gene:	KCNB2 / 9312	HGNCID:	6232	Length:	911	Species:	Homo sapiens

Alignment Length:	597	Identity:	196/597 - (32%)
Similarity:	307/597 - (51%)	Gaps:	109/597 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RVVINVSGLRFETQLRTLNQFPDTLLGDPARRLR-------------YFDPLRNEYFFDRSRPSF 149
            ||.|||.||..|...|||::.|.|.||    :||             .::...|||||||...:|
Human    36 RVKINVGGLNHEVLWRTLDRLPRTRLG----KLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96

  Fly   150 DAILYYYQSGGRLRRPVNVPLDVFSEEI----------------KFYELGDQAINKFREDEGFIK 198
            .:||.:|:: |:|.....:....|.:|:                ::::..:|...:.|.:...::
Human    97 TSILNFYRT-GKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMR 160

  Fly   199 EEERPLPDN----EKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFN 259
            |.|....||    :|::|:|.|.|.|.||.||:::||:|:..|:||.:...|.||||.:
Human   161 EREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQ------ 219

  Fly   260 TTTNGTKIEEDEVPDITDPFFL--IETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIP 322
                    |.||...:.|...|  :|.:||.|||.|..:|||:.|||..|.:..:||||::||:|
Human   220 --------ETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILP 276

  Fly   323 YFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSL-AILRVIRLVRVFRIFKLSRHSKGLQILG 386
            |::|:.                ::..:||..|..:: .::::.|::|:.||.||:|||.|||.||
Human   277 YYVTIF----------------LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLG 325

  Fly   387 RTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPV 451
            .||:.|..||||||.||.:|:::|||.|:|||...|::.|.|||..||||.:|||||||||:.|.
Human   326 FTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPK 390

  Fly   452 GVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE---------EMQSQNFNHVTSCPY 507
            .:.|||||.||.|||||.||||:|:||:||:.||..:..||         |...:|.:.|:.  .
Human   391 TLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSM--N 453

  Fly   508 LPGTLGQHM-------KKSSLSESSSDMMDLDDGVE------STPGLTETHPGRSAVAPFLGAQQ 559
            |.....:.|       :|:..|.::.|..| |:.:.      :...|:||...:|....:....|
Human   454 LKDAFARSMELIDVAVEKAGESANTKDSAD-DNHLSPSRWKWARKALSETSSNKSFENKYQEVSQ 517

  Fly   560 ----QQQQPVASSLSMSIDKQ-LQHPLQQLTQTQLYQQQQ---QQQQQQQNGFKQQQQQ-----T 611
                :|....:||....:..| |:....::|:||.:....   |::.::.:.::::.:.     .
Human   518 KDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCP 582

  Fly   612 QQQLQQQQSHTI 623
            |:||...|:..|
Human   583 QEQLAVAQTEVI 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	32/116 (28%)
		BTB	99..182	CDD:197585	31/111 (28%)
		Ion_trans	274..488	CDD:278921	103/216 (48%)
		Ion_trans_2	403..479	CDD:285168	46/75 (61%)
KCNB2	NP_004761.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		BTB	37..143	CDD:197585	31/110 (28%)
		BTB_2	37..136	CDD:280393	31/103 (30%)
		Ion_trans	230..428	CDD:278921	102/213 (48%)
		Ion_trans_2	341..422	CDD:285168	50/80 (63%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	381..386		4/4 (100%)
		Kv2channel	471..759	CDD:281514	24/125 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..534		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..571		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..665
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..739
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	760..865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810