Protein Alignment Sh and KCNG4

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_758857.1
• Gene: KCNG4 / 93107
• HGNCID: 19697
• Length: 519
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 156/549 - (28%)
• Similarity: 253/549 - (46%)
• Gaps: 104/549 - (18%)

  Fly    46 QLREQQLQRNSLDG--YGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRF 108
            ||....::..|:.|  |..:.|:.:.|.               .|:    |..:.::|||.|.|:
Human    25 QLLSSPMETPSIKGLYYRRVRKVGALDA---------------SPV----DLKKEILINVGGRRY 70

  Fly   109 ETQLRTLNQFPDTLLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAILYYYQSGG 160
            .....||::||.:.|.    :||.             :|....|:|||||..:|..|:.:..:|.
Human    71 LLPWSTLDRFPLSRLS----KLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGK 131

  Fly   161 RLRRPVNVPLDVFSEEIKFYELGD---------QAINKFREDEGFIK-----------EEERPLP 205
            .:.......|. |.||:.::.:.:         :.:.|..|.|...|           |..||..
Human   132 LVLLQEMCALS-FQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPAS 195

  Fly   206 DNEK----QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTK 266
            .:.:    ..::..:.|.|:|....:|.|.:|:..:..:.|..|:.|:|:.             :
Human   196 HSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDL-------------R 247

  Fly   267 IEED--EVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLAT 329
            .|||  |........|::||:|:.||:.|..:||:...:|..|.:..:|:|||:||.||:::||
Human   248 AEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLA- 311

  Fly   330 VVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMR 394
             |:||.     |:....|...|..:.:.| :|||:|.:|:..:.:|:|||.|||.||.|::...|
Human   312 -VSEEP-----PEDGERPSGSSYLEKVGL-VLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTR 369

  Fly   395 ELGLLIFFLFIGVVLFSSAVYFAEAGSDSSF-FKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIV 458
            |.|||:.||.:.:.|||..||.||..|.... |.|||..:|||:::|||||||||.|..|.|::|
Human   370 EFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMV 434

  Fly   459 GSLCAIAGVLTIALPVPVIVSNFNYFY-HRETDQEEMQS-----QNFNHVTSCPYL-PGTLGQHM 516
            .....::|:|.:|.|...|...|::.| ..:.:||::|:     ||....:.|..| |....:|
Human   435 ALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEH- 498

  Fly   517 KKSSLSESSSDMMDLDDGVESTPGLTETH 545
                     ..|.|::|.:...|.|...|
Human   499 ---------ELMNDVNDLILEGPALPIMH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	26/109 (24%)
		BTB	99..182	CDD:197585	26/95 (27%)
		Ion_trans	274..488	CDD:278921	85/215 (40%)
		Ion_trans_2	403..479	CDD:285168	34/76 (45%)
KCNG4	NP_758857.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		156/549 (28%)
		BTB	61..161	CDD:197585	26/104 (25%)
		BTB_2	61..160	CDD:280393	26/103 (25%)
		Ion_trans	262..465	CDD:278921	85/210 (40%)
		Ion_trans_2	377..459	CDD:285168	36/81 (44%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	418..423		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810