DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and KCNQ4

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_004691.2 Gene:KCNQ4 / 9132 HGNCID:6298 Length:695 Species:Homo sapiens


Alignment Length:78 Identity:15/78 - (19%)
Similarity:27/78 - (34%) Gaps:18/78 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 KLFICVCCNWSFGTEIYLKCHEECMKSTGRPGLLKPLAMPMTAPAREASALNTDPQNGSD----- 125
            ||.:|       ...:..:.....:|:.|:......||  :.:|....:.|.:.|:.|.:     
Human    45 KLKVC-------ALRVSSRARSRILKAGGKILTFDQLA--LESPKGRGTVLLSGPRKGREVYRHF 100

  Fly   126 ----DVPHSSPSP 134
                ..|||...|
Human   101 GKAPGTPHSHTKP 113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 10/47 (21%)
Ion_trans 226..488 CDD:459842
KCNQ4NP_004691.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Ion_trans 98..330 CDD:459842 4/16 (25%)
Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937 342..351
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..480
KCNQ_channel 464..647 CDD:460954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..515
Interaction with CALM. /evidence=ECO:0000250|UniProtKB:P51787 535..549
C-terminal assembly domain (tetramerization). /evidence=ECO:0000269|PubMed:17329207 546..650
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..606
Blue background indicates that the domain is not in the aligned region.

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