Protein Alignment Sh and KCNK5

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_003731.1
• Gene: KCNK5 / 8645
• HGNCID: 6280
• Length: 499
• Species: Homo sapiens
• Alignment Length: 167
• Identity: 32/167 - (19%)
• Similarity: 54/167 - (32%)
• Gaps: 67/167 - (40%)

  Fly   399 LIFFLFIGVVLF----------SSAVYFAE----------AGSE--------------------- 422
            :||:|.||..:|          :...|:.:          .|.|
Human    12 IIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITG 76

  Fly   423 NSFFK--SIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 485
            |..|.  :.|:|..:|...:||:|||::.|....|::   .|...|:..:.|.:..|.:...:|.
Human    77 NQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRL---FCVFYGLFGVPLCLTWISALGKFFG 138

  Fly   486 HRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLS 522
            .|..                     .|||.:.|..:|
Human   139 GRAK---------------------RLGQFLTKRGVS 154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885
		Ion_trans	226..488	CDD:459842	26/131 (20%)
KCNK5	NP_003731.1	Ion_trans_2	<83..137	CDD:462301	14/56 (25%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	98..103		3/4 (75%)
		Ion_trans_2	171..243	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	203..208
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..335
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..388
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..499