Protein Alignment Sh and Kcnq1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_114462.2
• Gene: Kcnq1 / 84020
• RGDID: 621503
• Length: 669
• Species: Rattus norvegicus
• Alignment Length: 384
• Identity: 91/384 - (23%)
• Similarity: 149/384 - (38%)
• Gaps: 82/384 - (21%)

  Fly   197 IKEEERP-LPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNT 260
            |....|| |.....|.:|:...|.|...:.  .|...:||:|:|..:||  ..|...:.|....|
  Rat    93 IYSTRRPLLARTHIQGRVYNFLERPTGWKC--FVYHFTVFLIVLVCLIF--SVLSTIEQYAALAT 153

  Fly   261 TTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRF--LACPNK-------LNFCRDVMNVID 316
            .|                .|.:|.:.:::|..|..||.  ..|.:|       |.|.|..:::||
  Rat   154 GT----------------LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIID 202

  Fly   317 IIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKG 381
            :|.::...:.|..                    .|..|..:.:.:|.||.:::.|:..:.|....
  Rat   203 LIVVVASMVVLCV--------------------GSKGQVFATSAIRGIRFLQILRMLHVDRQGGT 247

  Fly   382 LQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSF----FKSIPDAFWWAVVTMTT 442
            .::||..:....:||...::..|:|::..|..||.||..:.|..    |.|..||.||.|||:||
  Rat   248 WRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTT 312

  Fly   443 VGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ---------- 497
            :||||..|....||.:.|..::..:...|||..::.|.|.....::..|:....|
  Rat   313 IGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQT 377

  Fly   498 --------NFNHVTSCPYLPGTLGQHM--------KKSSLSESSSDMMDLDDGVESTPG 540
                    |.:..|...|:......|.        |||.:.:.....:|.|:|:  :||
  Rat   378 AWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSVMVKKKKFKLDKDNGL--SPG 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	8/26 (31%)
		Ion_trans	226..488	CDD:459842	69/274 (25%)
Kcnq1	NP_114462.2	Ion_trans	123..359	CDD:459842	69/273 (25%)
		Interaction with KCNE3. /evidence=ECO:0000250|UniProtKB:P51787	238..246		1/7 (14%)
		Interaction with CALM. /evidence=ECO:0000250|UniProtKB:P51787	370..382		0/11 (0%)
		KCNQ_channel	<511..617	CDD:460954
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000250|UniProtKB:P51787	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000250|UniProtKB:P51787	535..572
		Interaction with AKAP9. /evidence=ECO:0000250|UniProtKB:P51787	588..616
		C-terminal assembly domain (tetramerization). /evidence=ECO:0000250|UniProtKB:P51787	589..620