DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcns3

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001376159.1	Gene:	Kcns3 / 83588	RGDID:	621527	Length:	491	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	151/459 - (32%)
Similarity:	231/459 - (50%)	Gaps:	83/459 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLG------DPARRLRYFDPLR---NEYFFDRSRPSFDAI 152
            |.|.:||.|.:......||.:||.|.||      .....|...|...   .||:|||:...|..:
  Rat    15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYV 79

  Fly   153 LYYYQSGGRLRRPVNVPLDVFS--EEIKFYELG------------------------DQAIN--- 188
            |.:|.:|   :..|...|.|||  :||:::.:.                        ||..|
  Rat    80 LNFYYTG---KLHVMEELCVFSFCQEIEYWGINELFIDSCCSSRYQERKEESHEKDWDQKSNDVS 141

  Fly   189 ---KFREDEGFIKEEER--PLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLET 248
               .|.|...|.||.|:  .|...:.::|:|:..|.|....:|:::||.|:.|:|.|||..|:.:
  Rat   142 TDSSFEESSLFEKELEKFDELRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHS 206

  Fly   249 LPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFL-IETLCIIWFTFELTVRFLACPNKLNFCRDVM 312
            :.||                ::|..::.||... :|..||.|||.||.:|.:|.|::..|.::.:
  Rat   207 MSEF----------------QNEDGEVDDPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPL 255

  Fly   313 NVIDIIAIIPYFITLATVVAEE--EDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKL 375
            |:||.::|||::.|||....||  ||..|:.|                 :::::||:|:|||.||
  Rat   256 NIIDFVSIIPFYATLAVDTKEEESEDIENMGK-----------------VVQILRLMRIFRILKL 303

  Fly   376 SRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTM 440
            :|||.||:.||.||:.|..|:|||:.||.:|:.:||..:|..|....:|...|||..:|||.::|
  Rat   304 ARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDELASSLTSIPICWWWATISM 368

  Fly   441 TTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSC 505
            |||||||..||.:.|||:.|.|.|.|:|.:|||:.:|.:.|:.:|.::.|.:..|... :....|
  Rat   369 TTVGYGDTHPVTLAGKIIASTCIICGILVVALPITIIFNKFSKYYQKQKDMDVDQCSE-DPPEKC 432

  Fly   506 PYLP 509
            ..||
  Rat   433 HELP 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	31/122 (25%)
		BTB	99..182	CDD:197585	29/93 (31%)
		Ion_trans	274..488	CDD:278921	89/216 (41%)
		Ion_trans_2	403..479	CDD:285168	35/75 (47%)
Kcns3	NP_001376159.1	BTB_POZ_KCNS3	15..122	CDD:349735	30/109 (28%)
		Ion_trans	184..417	CDD:395416	102/265 (38%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810