DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and kcnc4

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001182125.1 Gene:kcnc4 / 799410 ZFINID:ZDB-GENE-060503-773 Length:603 Species:Danio rerio


Alignment Length:517 Identity:186/517 - (35%)
Similarity:275/517 - (53%) Gaps:89/517 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GHGFGGGPQHFEPIPHDHDFCE---RVVINVSGLRFETQLRTLNQFPDTLLG---------DPAR 128
            |...|..|.....:..:...||   :::|||.|.|.||...||...|.:.|.         :|..
Zfish    12 GRKSGNKPPSKSCLKEEMARCEDSDKIIINVGGTRHETYRSTLRTIPGSRLAWLADTDSQVNPDA 76

  Fly   129 RLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYEL----------- 182
            ......| .:|:||||....|..:|.||:: |:|..|.:|...:|.||:.|:.:           
Zfish    77 DTGQTHP-NSEFFFDRHPGIFAYVLNYYRT-GKLHCPADVCGPLFEEELAFWGIDETDVEPCCWM 139

  Fly   183 -------GDQAINKFREDEGFIKEEERPL---------PDNEK------QRKVWLLFEYPESSQA 225
                   .::|::.|...:....|:::.:         ||..:      |.|:|.|||.|.||:|
Zfish   140 TYRQHRDAEEALDIFEPPDPEDAEDDQDMPRRFGIEDSPDRSRGCCEVWQPKIWALFEDPYSSRA 204

  Fly   226 ARVVAIISVFVILLSIVIFCLET---LPEFKHYKVFNTTTNGTKIEE--DEVPDITDPFFLIETL 285
            |||:|.:|:|.||:||..|||||   ..||.::....:.||.|.|.:  |..|.:|    ::|.:
Zfish   205 ARVIAFVSLFFILVSITNFCLETHEAFFEFHNHTDTKSATNSTTIIQVMDTKPVLT----VVEGI 265

  Fly   286 CIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDK 350
            |::|||||..||.:.|||||.|.::.:|:||.:||:|::               |.::.:....|
Zfish   266 CVVWFTFEFLVRIICCPNKLLFIKNQLNIIDFVAILPFY---------------LERSLIGNTSK 315

  Fly   351 SSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVY 415
            ::...  |..|||:|.||:.|||||:||..||::||.||:||:.|..|||.||.:||::|::.:|
Zfish   316 AAKDV--LGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASVNEFCLLIIFLALGVLIFATMIY 378

  Fly   416 FAE---------AGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIA 471
            :||         :|.:.:.||:||.|||||||||||:|||||.|....|.|||:|||||||||||
Zfish   379 YAERISADPDDPSGCNHTHFKNIPIGFWWAVVTMTTLGYGDMVPKTWLGMIVGALCAIAGVLTIA 443

  Fly   472 LPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTL---GQHMKKSSLSESSSDMMD 530
            :||||||:||..:|.....::::..:...|..:    ||.:   |...|..|.|..:|...|
Zfish   444 MPVPVIVNNFGMYYSLAMAKQKLPKKKKKHNPN----PGMVLDSGSFGKSESNSPRNSTQSD 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 30/114 (26%)
BTB 99..182 CDD:197585 30/91 (33%)
Ion_trans 274..488 CDD:278921 104/222 (47%)
Ion_trans_2 403..479 CDD:285168 49/84 (58%)
kcnc4NP_001182125.1 amino terminal assembly domain 1..206 50/195 (26%)
Potassium_chann 1..29 CDD:288290 3/16 (19%)
BTB 38..144 CDD:197585 30/107 (28%)
BTB_2 38..136 CDD:280393 30/99 (30%)
S1-S6 membrane domain 207..516 134/320 (42%)
Ion_trans 248..461 CDD:278921 107/233 (46%)
Ion_trans_2 365..451 CDD:285168 50/85 (59%)
post S6 proximal carboxyl terminal domain 517..581
distal carboxyl terminus 582..603
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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