Protein Alignment Sh and kcng1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001103880.1
• Gene: kcng1 / 796774
• ZFINID: ZDB-GENE-080220-5
• Length: 521
• Species: Danio rerio
• Alignment Length: 504
• Identity: 146/504 - (28%)
• Similarity: 234/504 - (46%)
• Gaps: 110/504 - (21%)

  Fly    99 VVINVSGLRFETQLRTLNQFPDTLLGDPARRLRY-------------FDPLRNEYFFDRSRPSFD 150
            |:|||.|||::....||..||.:.||    :||.             :|.:.||:|||||..:|.
Zfish    72 VIINVGGLRYQFPWTTLEDFPLSRLG----QLRLCSTFDEIMHICDDYDVVHNEFFFDRSPCAFR 132

  Fly   151 AILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGD------------QAINKFREDEGFIKEEERP 203
            .||.:.:: |:||....:....|.||:.::.:.:            |.:.:..|.|...:|:|..
Zfish   133 TILTFLRA-GKLRSLREMCALSFQEELLYWGVPEESLEWCCRRRLLQRVEECDELERVAEEDEED 196

  Fly   204 LPDNEK-----------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKV 257
            ..|:|.           ..|:..:.|.|.|....::.|.:||..:.::.:...:.|:|..:
Zfish   197 EDDSESGLARESRLGRCMGKLRDMVEKPHSGLPGKIFACLSVLFVTITAINLSISTMPAMR---- 257

  Fly   258 FNTTTNGTKIEEDEVPDITD---PFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIA 319
                      ||:|....:.   ..|::||:|:.||:.|.|:||:...:||.|.|..:|:||:||
Zfish   258 ----------EEEETGKCSQMCYNIFIVETVCVAWFSLEFTLRFIQDRSKLAFLRRPLNLIDVIA 312

  Fly   320 IIPYFITL---ATVVAEEE--------DTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIF 373
            |:||:|||   :|...|:.        |.:.|                   :|||:|.:|:..:.
Zfish   313 ILPYYITLVVDSTSTGEKRLGSGSSYLDKVGL-------------------VLRVLRALRILYVM 358

  Fly   374 KLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAE-AGSENSFFKSIPDAFWWAV 437
            :|:|||.|||.||.|.:...||.|||:.||.:.:.|||..:|..| ..:....|.|||..:||||
Zfish   359 RLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFSPLLYLIENEAAATREFSSIPATYWWAV 423

  Fly   438 VTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHV 502
            :||||||||||.|..:.|::|.....::|:|.:|.||..|...|:..|.....:::...|...|
Zfish   424 ITMTTVGYGDMVPRSIPGQVVALSSILSGILLMAFPVTSIFHTFSRSYVELKQEQQRLLQRRTH- 487

  Fly   503 TSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVEST---PGLTETHPGR 548
                        .:.:|.::...||:     .:||.   |.::..|..|
Zfish   488 ------------FLLRSRIAGLGSDL-----SLESDVLFPSVSSEHRNR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	42/159 (26%)
		Ion_trans	226..488	CDD:459842	93/276 (34%)
kcng1	NP_001103880.1	BTB_POZ_KCNG1_2	67..180	CDD:349728	33/112 (29%)
		Ion_trans	231..475	CDD:459842	93/276 (34%)