DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcna1a

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_005163101.1	Gene:	kcna1a / 795942	ZFINID:	ZDB-GENE-110408-15	Length:	492	Species:	Danio rerio

Alignment Length:	465	Identity:	317/465 - (68%)
Similarity:	366/465 - (78%)	Gaps:	27/465 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GGPQHFEPIPH-DHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDR 144
            |.||...|..| ||:.|||||||::||||||||:||.|||:||||:|.:|:||||||||||||||
Zfish    17 GHPQDTYPPDHDDHECCERVVINIAGLRFETQLKTLAQFPETLLGNPKKRMRYFDPLRNEYFFDR 81

  Fly   145 SRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEK 209
            :||||||||||||||||||||.|||||:|||||||||||.:|:.|||||||||:|||||||:.|.
Zfish    82 NRPSFDAILYYYQSGGRLRRPANVPLDMFSEEIKFYELGVEAMEKFREDEGFIREEERPLPEKEF 146

  Fly   210 QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFK-----HYKVFNTTTNGTKIEE 269
            ||::|||||:||||..||.:||:||.|||:||||||||||||.|     ..|:...||...|
Zfish   147 QRQIWLLFEHPESSGPARGIAIVSVMVILISIVIFCLETLPELKEDPEGRIKIIGNTTYYYK--- 208

  Fly   270 DEVPDI-TDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAE 333
               |.| .||||:|||||||||:|||.|||.|||:|..|.:::||.|||:|||||||||.|.:||
Zfish   209 ---PSILADPFFIIETLCIIWFSFELIVRFFACPSKAAFFKNMMNTIDIVAIIPYFITLGTELAE 270

  Fly   334 EEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGL 398
            |:|          .::....||.||||||||||||||||||||||||||||||:|||||||||||
Zfish   271 EQD----------GKEGKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGL 325

  Fly   399 LIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCA 463
            |||||||||:|||||||||||....|:|.||||.||||||:|||||||||.||.:.|||||||||
Zfish   326 LIFFLFIGVILFSSAVYFAEAEEKESYFSSIPDAFWWAVVSMTTVGYGDMVPVTIGGKIVGSLCA 390

  Fly   464 IAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDM 528
            ||||||||||||||||||||||||||:.|| |:|..|  .|.|.:... ....::||.:.|.|:.
Zfish   391 IAGVLTIALPVPVIVSNFNYFYHRETEGEE-QAQLLN--VSNPNIASD-SNSSRRSSSTVSKSEY 451

  Fly   529 MDLDDGVEST 538
            |::|..:.::
Zfish   452 MEIDGDINNS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	73/87 (84%)
		BTB	99..182	CDD:197585	70/82 (85%)
		Ion_trans	274..488	CDD:278921	162/214 (76%)
		Ion_trans_2	403..479	CDD:285168	62/75 (83%)
kcna1a	XP_005163101.1	BTB	36..130	CDD:197585	77/93 (83%)
		BTB_2	36..127	CDD:280393	74/90 (82%)
		Ion_trans	205..415	CDD:278921	164/225 (73%)
		Ion_trans_2	330..406	CDD:285168	62/75 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I952
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I890
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	1	1.000	-	-		otm24559
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3654
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910