Protein Alignment Sh and Kcng4

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_080010.2
• Gene: Kcng4 / 66733
• MGIID: 1913983
• Length: 506
• Species: Mus musculus
• Alignment Length: 553
• Identity: 159/553 - (28%)
• Similarity: 261/553 - (47%)
• Gaps: 121/553 - (21%)

  Fly    66 LSSQDEEGGAG-HGFGG---------GPQ----------------HFEPIPHDHDFCERVVINVS 104
            :||:|.:...| |.||.         ||:                :.:..|..:  .:.:::||.
Mouse     3 MSSRDRDLHPGHHHFGSCSPLSQLWPGPEPKSVKGLYYSRARKVGNQDASPEAN--LKEILVNVG 65

  Fly   105 GLRFETQLRTLNQFPDTLLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAILYYY 156
            |.|:.....||:.||.:.|.    |||.             :|....|:||||:..:|..|:.:.
Mouse    66 GQRYLLPWSTLDAFPLSRLS----RLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFL 126

  Fly   157 QSGGRLRRPVNVPLDVFSEEIKFYELGDQAINK---------------FREDEGFIKEEERPLPD 206
            .:|..:.......|. |.||:.::.:.:..:.:               .|.:|...::::|....
Mouse   127 AAGKLVLLREMCALS-FREELSYWGIEETNLERCCLRKLLKKLEEAAELRREEAAQRQQQRQACH 190

  Fly   207 NEKQRKVWL--------LFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTN 263
            :|.|...|.        :.|.|:|....:|.|.:||..:..:.|..|:.|:|:|:
Mouse   191 SEVQASRWARSMNQLREMVEDPQSGLPGKVFACLSVLFVATTAVSLCVSTMPDFR---------- 245

  Fly   264 GTKIEEDEVPDITDP---FFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFI 325
                .|:...:.|..   .|::|::|:.||:.|..:||:..|||..|.|..:|||||:||.||::
Mouse   246 ----AEEGKGECTRKCYYIFVVESICVAWFSLEFCLRFVQAPNKCQFFRGPLNVIDILAISPYYV 306

  Fly   326 TLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLK 390
            :||  |::|.     |:|...|...|..:.:.| :|||:|.:|:..:.:|:|||.|||.||.|::
Mouse   307 SLA--VSDES-----PEAGERPSSSSYLEKVGL-VLRVLRALRILYVMRLARHSLGLQTLGLTVR 363

  Fly   391 ASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSF-FKSIPDGFWWAVVTMTTVGYGDMRPVGVW 454
            ...||.|||:.||.:.|.|||..||.||..|.... |.|||..:|||:::|||||||||.|..|.
Mouse   364 RCAREFGLLMLFLAVAVTLFSPLVYVAENESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVP 428

  Fly   455 GKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKK 518
            |::|.....::|:|.:|.|...|...|::.| ..:.:||::|::                  :::
Mouse   429 GQMVALSSILSGILIMAFPATSIFHTFSHSYLELKREQEQVQAR------------------LRR 475

  Fly   519 SSLSESSSD---MMDLDDGVESTPGLTETHPGR 548
            ...:.|:|:   :.|:||.|..  |||.  |||
Mouse   476 LQNTNSASERELLSDVDDLVPE--GLTS--PGR 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	25/100 (25%)
		BTB	99..182	CDD:197585	25/95 (26%)
		Ion_trans	274..488	CDD:278921	90/218 (41%)
		Ion_trans_2	403..479	CDD:285168	35/76 (46%)
Kcng4	NP_080010.2	BTB_POZ	58..167	CDD:365784	25/113 (22%)
		Ion_trans	219..463	CDD:366146	100/265 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	416..421		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810