Protein Alignment Sh and Kcnk10

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_075584.1
• Gene: Kcnk10 / 65272
• RGDID: 619732
• Length: 538
• Species: Rattus norvegicus
• Alignment Length: 492
• Identity: 95/492 - (19%)
• Similarity: 157/492 - (31%)
• Gaps: 161/492 - (32%)

  Fly   231 IISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELT 295
            ::::||:   :|::.:               |.|......|.|                  ||.:
  Rat    72 VVAIFVV---VVVYLV---------------TGGLVFRALEQP------------------FESS 100

  Fly   296 VRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQA----- 355
            .:......|..|.|      |.|.:.|.  .|.|::   :..|:...|.|||...|||.:
  Rat   101 QKNTIALEKAEFLR------DHICVSPQ--ELETLI---QHALDADNAGVSPVGNSSNSSSHWDL 154

  Fly   356 -----MSLAILRVIRLVRVF------RIFKLSRHSKGLQILGRTLKASMRELGLL---------- 399
                 .:..::..|....:.      :||.:.....|:.:.|..|.....:||.:
  Rat   155 GSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEK 219

  Fly   400 -----------------IFFLFIGVVLFSS--AVYFAEAGSENSFFKSIP-----DAFWWAVVTM 440
                             |.|:..|.::|.:  ||          .||.|.     ::.::.|||:
  Rat   220 VFRKKQVSQTKIRVISTILFILAGCIVFVTIPAV----------IFKYIEGWTALESIYFVVVTL 274

  Fly   441 TTVGYGDMTPVG-------------VWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE 492
            ||||:||....|             ||..|:..|...|.||:       ::.::.....::|.:|
  Rat   275 TTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLS-------MIGDWLRVLSKKTKEE 332

  Fly   493 EMQSQNFNHVTSCPYLPGTLGQH---MKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPF 554
                            .|.:..|   .|.:..:|.......|  .||....|......||.....
  Rat   333 ----------------VGEIKAHAAEWKANVTAEFRETRRRL--SVEIHDKLQRAATIRSMERRR 379

  Fly   555 LGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQNGFKQQQQQTQQQLQQQQ 619
            ||..|:     |.||.| :..:.:.....|...:.....|:....:.|..:.:..      :|..
  Rat   380 LGLDQR-----AHSLDM-LSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGP------EQLN 432

  Fly   620 SHTINASAAAATSGSGS-SGLTMRHNNALAVSIETDV 655
            .|...||.....:..|| |.||.|.|..|..::..||
  Rat   433 KHGQGASEDNIINKFGSTSKLTKRKNKDLKKTLPEDV 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885
		Ion_trans	226..488	CDD:459842	59/319 (18%)
Kcnk10	NP_075584.1	Ion_trans_2	<150..206	CDD:462301	6/55 (11%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	167..172		1/4 (25%)
		Ion_trans_2	244..323	CDD:462301	23/95 (24%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	276..281		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..444		6/37 (16%)