DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcnd3

DIOPT Version :9

Sequence 1:NP_001303569.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_001257891.1 Gene:Kcnd3 / 65195 RGDID:68394 Length:655 Species:Rattus norvegicus


Alignment Length:575 Identity:187/575 - (32%)
Similarity:294/575 - (51%) Gaps:102/575 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGR 161
            |.:|:||||.||:|...||.::||||||...:.. :|:....||||||....|..:|.:|:: |:
  Rat    40 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEF-FFNEDTKEYFFDRDPEVFRCVLNFYRT-GK 102

  Fly   162 LRRPVNVPLDVFSEEIKFYE-----LGDQAINKFREDEGFIKEEERPLPDNEKQ----------- 210
            |..|....:..:.:|:.||.     :||....::::.:.  :..||.:.|||.:           
  Rat   103 LHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKR--ENAERLMDDNESENNQESMPSLSF 165

  Fly   211 -RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVP- 273
             :.:|..||.|.:|..|.|...::.|.|.:|::...:||:|        ..|..|:|    |:| 
  Rat   166 RQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVP--------CGTVPGSK----ELPC 218

  Fly   274 --DITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEED 336
              ..:..||.::|.|::.||.|..:|..|.|::..|.|.||::||::||:||:|.|.        
  Rat   219 GERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLV-------- 275

  Fly   337 TLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIF 401
                         .::|:.:|.|.: .:|:.|||||||.||||:||:|||.|||:...|||.|:|
  Rat   276 -------------MTNNEDVSGAFV-TLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLF 326

  Fly   402 FLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAG 466
            .|.:.:::|::.:::||.||.:|.|.|||..||:.:|||||:|||||.|..:.|||.||:|:::|
  Rat   327 SLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSG 391

  Fly   467 VLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHV---------TSCPYLPGTLGQHMKKSSLS 522
            ||.||||||||||||:..||:....::.::|....:         :|..||      |.|::.| 
  Rat   392 VLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYL------HSKRNGL- 449

  Fly   523 ESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQT 587
                    |::.:|.|....|.|.|::                 :||..|....|.|.|::.|..
  Rat   450 --------LNEALELTGTPEEEHMGKT-----------------TSLIESQHHHLLHCLEKTTGL 489

  Fly   588 QLYQQQQQQQQQQQNGFKQQQQQTQQQLQQ--QQSHTINASAAAATSGSGSSGLT 640
            . |.........:.:..|..:...:|..:|  .:|...|..:..:.|.|..||||
  Rat   490 S-YLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLT 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_001303569.1 BTB_2 99..187 CDD:280393 34/92 (37%)
BTB 99..182 CDD:197585 32/87 (37%)
Ion_trans 274..488 CDD:278921 97/213 (46%)
Ion_trans_2 403..479 CDD:285168 41/75 (55%)
Kcnd3NP_001257891.1 Interaction with KCNIP2. /evidence=ECO:0000250 2..20
Shal-type 3..28 CDD:288455
BTB 42..139 CDD:197585 34/98 (35%)
BTB_2 42..131 CDD:280393 33/90 (37%)
Ion_trans 217..412 CDD:278921 97/216 (45%)
Ion_trans_2 328..408 CDD:285168 45/79 (57%)
Selectivity filter. /evidence=ECO:0000250 367..372 3/4 (75%)
DUF3399 442..563 CDD:288712 29/135 (21%)
Mediates dendritic targeting. /evidence=ECO:0000250 474..489 5/14 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..565 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..647
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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