DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcna6

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_076444.1	Gene:	Kcna6 / 64358	RGDID:	62083	Length:	530	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	312/530 - (58%)
Similarity:	364/530 - (68%)	Gaps:	88/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QDEEGGAGHGFGGGPQHFEPIPHDHDFC---ERVVINVSGLRFETQLRTLNQFPDTLLGDPARRL 130
            |:.|||.|                   |   ||:|||:||||:|||||||:.|||||||||.||:
  Rat    29 QEAEGGGG-------------------CCSSERLVINISGLRYETQLRTLSLFPDTLLGDPGRRV 74

  Fly   131 RYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEG 195
            |:||||||||||||:||||||||||||||||||||||||||:|.|||:||:|||:|:..||||||
  Rat    75 RFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFYQLGDEALAAFREDEG 139

  Fly   196 FIK---EEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFK---- 253
            .:.   |:|:|||....||:|||||||||||..||.:||:||.|||:|||||||||||:|:
  Rat   140 CLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGR 204

  Fly   254 ------HYKVFNTTTNGTKIEEDEVPD----------------------------ITDPFFLIET 284
                  .....:..:.|:..||||..|                            .||||||:||
  Rat   205 GGSNEGSGTRMSPASRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLGGSFFTDPFFLVET 269

  Fly   285 LCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVS-PQ 348
            |||:||||||.|||.|||:|..|.|::||:||::||.||||||.|.:.:..:     :.||| ..
  Rat   270 LCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHE-----QQPVSGGS 329

  Fly   349 DKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSA 413
            .::..|||||||||||||||||||||||||||||||||:||:|||||||||||||||||:|||||
  Rat   330 GQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSA 394

  Fly   414 VYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIV 478
            ||||||....|.|.||||.||||||||||||||||.|:.|.||||||||||||||||||||||||
  Rat   395 VYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIV 459

  Fly   479 SNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTE 543
            |||||||||||:||| |.| :.||| |                .:.:.|:...|:|:........
  Rat   460 SNFNYFYHRETEQEE-QGQ-YTHVT-C----------------GQPTPDLKATDNGLGKPDFAEA 505

  Fly   544 THPGRSAVAP 553
            :...||:..|
  Rat   506 SRERRSSYLP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	73/87 (84%)
		BTB	99..182	CDD:197585	70/82 (85%)
		Ion_trans	274..488	CDD:278921	162/242 (67%)
		Ion_trans_2	403..479	CDD:285168	63/75 (84%)
Kcna6	NP_076444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		3/5 (60%)
		BTB_2	43..132	CDD:280393	74/88 (84%)
		BTB	43..126	CDD:197585	70/82 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..239		6/35 (17%)
		Ion_trans	260..469	CDD:278921	161/213 (76%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	361..374		10/12 (83%)
		Ion_trans_2	383..460	CDD:285168	64/76 (84%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	423..428		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000255	527..529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930