DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and Kcnq4

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001074611.1	Gene:	Kcnq4 / 60613	MGIID:	1926803	Length:	696	Species:	Mus musculus

Alignment Length:	399	Identity:	85/399 - (21%)
Similarity:	156/399 - (39%)	Gaps:	90/399 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 IISVFVILL---SIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTF 292
            :..||:.||   .:|:..|.|:.|  |.::.|                 :...::|.:.|:.|..
Mouse   101 VYHVFIFLLVFSCLVLSVLSTIQE--HQELAN-----------------ECLLILEFVMIVVFGL 146

  Fly   293 ELTV---------RFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQ 348
            |..:         |:.....:..|.|....|||.|.    |:....|:|.
Mouse   147 EYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIV----FVASVAVIAA--------------- 192

  Fly   349 DKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSA 413
             .:.....:.:.||.:|.:::.|:.::.|.....::||..:.|..:||....:..|:.::..|..
Mouse   193 -GTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFL 256

  Fly   414 VYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIV 478
            ||.||..::|. |.|..|..||..:|:||:||||..|....|:::.:..|:.|:...|||..::.
Mouse   257 VYLAEKDANSD-FSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILG 320

  Fly   479 SNFN---YFYHRET--DQEEMQSQN--------FNHVTSCPYLPGT----------------LGQ 514
            |.|.   ...||:.  ::..|.:.|        ::..||..||..|                |.:
Mouse   321 SGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPSFRELALLFE 385

  Fly   515 HMKKS---SLSESSSDMMDLDDGVEST-PGLTETH-PGRSAVAPFLGAQQQQQQPVASSLSMSID 574
            |::::   .|.........:.||..|. |.:...| ||.::..|    .:..:..:...:.:|..
Mouse   386 HIQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSASFCP----GESSRMGIKDRIRISSS 446

  Fly   575 KQLQHPLQQ 583
            ::...|.:|
Mouse   447 QKRTGPSKQ 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393
		BTB	99..182	CDD:197585
		Ion_trans	274..488	CDD:278921	53/225 (24%)
		Ion_trans_2	403..479	CDD:285168	26/75 (35%)
Kcnq4	NP_001074611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		MIG-14_Wnt-bd	<93..191	CDD:284153	23/112 (21%)
		Ion_trans	127..331	CDD:278921	53/241 (22%)
		Ion_trans_2	247..321	CDD:285168	26/74 (35%)
		Selectivity filter. /evidence=ECO:0000250	284..289		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..484		2/11 (18%)
		KCNQ_channel	471..654	CDD:281513
		A-domain (Tetramerization). /evidence=ECO:0000250	546..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810