Protein Alignment Sh and Kcnv1

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_067729.1
• Gene: Kcnv1 / 60326
• RGDID: 621264
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 484
• Identity: 152/484 - (31%)
• Similarity: 237/484 - (48%)
• Gaps: 106/484 - (21%)

  Fly    52 LQRNSLDGYGSLPKLSS----QDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQL 112
            |..:|||. |||..|.|    .:.||             ||:.    ..:.:.:||.|.||....
  Rat    11 LDSSSLDS-GSLTSLDSSVFCSEGEG-------------EPLA----LGDCLTVNVGGSRFVLSQ 57

  Fly   113 RTLNQFPDTLLGDPA------RRLRYF-------------DPLRNEYFFDRSRPSFDAILYYYQS 158
            :.|:.||.|.||..|      |||...             :|:.||||||||..:|..:|:||::
  Rat    58 QALSCFPHTRLGKLAVVVASYRRLGALAAAPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRT 122

  Fly   159 GGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEE-------ERPLPDNEKQ------ 210
             |||.....:....|.:||:::.:.:.:|:....|..|.::|       ::...|.|.|
  Rat   123 -GRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTDDQESQHESEQD 186

  Fly   211 ----------RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGT 265
                      :|:|.:.|.|.||.|||:..:||:..:.:|||...|           .:...:..
  Rat   187 FSQGPCPTVRQKLWDILEKPGSSTAARIFGVISIIFVAVSIVNMAL-----------MSAELSWL 240

  Fly   266 KIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATV 330
            .::..|:         :|.:||.|||.|..:|||...::.:|.|.|.|:||::||:|::|||..
  Rat   241 NLQLLEI---------LEYVCISWFTGEFILRFLCVKDRCHFLRKVPNIIDLLAILPFYITLLV- 295

  Fly   331 VAEEEDTLNLPKAPVSPQDKSSNQAMSL----AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKA 391
                 ::|:           .|:....|    .:::|:||:|..|:.||.|||.||:.||.|:..
  Rat   296 -----ESLS-----------GSHTTQELENVGRLVQVLRLLRALRMLKLGRHSTGLRSLGMTITQ 344

  Fly   392 SMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGK 456
            ...|:|||:.||.:|:.:||:..||||....::.|.|:|.|:|||..:||||||||:.|....||
  Rat   345 CYEEVGLLLLFLSVGISIFSTIEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGK 409

  Fly   457 IVGSLCAIAGVLTIALPVPVIVSNFNYFY 485
            ||..:|.::|:|.:|||:.:|...|:..|
  Rat   410 IVAFMCILSGILVLALPIAIINDRFSACY 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	45/167 (27%)
		Ion_trans	226..488	CDD:459842	91/264 (34%)
Kcnv1	NP_067729.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/9 (44%)
		BTB_POZ	44..163	CDD:453885	37/119 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..192		3/20 (15%)
		Ion_trans	212..438	CDD:459842	90/262 (34%)
		Selectivity filter. /evidence=ECO:0000250	395..400		4/4 (100%)