DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sh and Kcnk1

DIOPT Version :10

Sequence 1:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_067720.1 Gene:Kcnk1 / 59324 RGDID:621447 Length:336 Species:Rattus norvegicus


Alignment Length:186 Identity:33/186 - (17%)
Similarity:65/186 - (34%) Gaps:57/186 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   398 LLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTP------------ 450
            :|:.|:.:....|..|..|:....:.:|.:|    |::..::::|:|.||..|            
  Rat   185 VLLGFVTVSCFFFIPAAVFSVLEDDWNFLES----FYFCFISLSTIGLGDYVPGEGYNQKFRELY 245

  Fly   451 -VGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQ 514
             :|:...::..|.|:..||.....:..: ..|...::.:.|::|.|.....|             
  Rat   246 KIGITCYLLLGLIAMLVVLETFCELHEL-KKFRKMFYVKKDKDEDQVHIMEH------------- 296

  Fly   515 HMKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLS 570
                        |.:......|...||.|              :|:|.:|..:|.|
  Rat   297 ------------DQLSFSSITEQAAGLKE--------------EQKQNEPFVASQS 326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShNP_728123.1 BTB_POZ 97..223 CDD:453885
Ion_trans 226..488 CDD:459842 19/102 (19%)
Kcnk1NP_067720.1 Ion_trans_2 <98..157 CDD:462301
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:O00180 117..122
Ion_trans_2 191..267 CDD:462301 16/79 (20%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:O00180 225..230 2/4 (50%)
Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250|UniProtKB:O00180 293..299 2/30 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..336 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

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