DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcna7

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_701294.4	Gene:	kcna7 / 572481	ZFINID:	ZDB-GENE-120215-257	Length:	233	Species:	Danio rerio

Alignment Length:	245	Identity:	131/245 - (53%)
Similarity:	168/245 - (68%)	Gaps:	25/245 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GLGEDRQHRKKQQQQQQHQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEG 73
            |.||:..:.|.:.:.|..:    |..|..||:.:          |||..: .|...|...:.|..
Zfish     4 GEGEEESNSKMEDKTQTEE----EVSESDKKLKD----------QRNKAE-KGDKEKGEKKRENR 53

  Fly    74 GAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRN 138
            .:|..:.||          ....||:.|||||:|:|||:|||.||||:|||||.|||||||||||
Zfish    54 RSGSTWRGG----------WALSERLAINVSGMRYETQIRTLAQFPDSLLGDPRRRLRYFDPLRN 108

  Fly   139 EYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERP 203
            |.|.||:|..||||||:||||||||||.|||||||.:|::|||||:..:.:|:|||||.|||.||
Zfish   109 EIFLDRNRFCFDAILYFYQSGGRLRRPANVPLDVFMDELRFYELGEDIMARFKEDEGFPKEEPRP 173

  Fly   204 LPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFK 253
            ||::|.|||:|:|||:||||..||::|||||.||::||:||||||||:|:
Zfish   174 LPESEFQRKIWMLFEHPESSGGARIIAIISVMVIVVSILIFCLETLPDFR 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	66/87 (76%)
		BTB	99..182	CDD:197585	63/82 (77%)
		Ion_trans	274..488	CDD:278921
		Ion_trans_2	403..479	CDD:285168
kcna7	XP_701294.4	BTB_2	71..160	CDD:280393	66/88 (75%)
kcna7	XP_701294.4	BTB	71..158	CDD:197585	66/86 (77%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.780