Protein Alignment Sh and kcna1b

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_699869.2
• Gene: kcna1b / 571208
• ZFINID: ZDB-GENE-140515-1
• Length: 493
• Species: Danio rerio
• Alignment Length: 464
• Identity: 314/464 - (67%)
• Similarity: 369/464 - (79%)
• Gaps: 26/464 - (5%)

  Fly    81 GGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRS 145
            |.||..:..|   :.|||||||:|||||||||:||.|||:||||:|.:|:||||||||||||||:
Zfish    19 GQPQDSQYSP---ECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRN 80

  Fly   146 RPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQ 210
            ||||||||||||||||||||||||||:|||||||||||::|:.|||||||||:||||||||||.|
Zfish    81 RPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIREEERPLPDNEFQ 145

  Fly   211 RKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFK-----HYKVFNTTTNGTKIEED 270
            |::|||||:||||..||.:||:||.|||:||||||||||||.|     ..:|...:|...|
Zfish   146 RQIWLLFEHPESSGPARGIAIVSVMVILISIVIFCLETLPELKEDPQGRLQVIGNSTFYYK---- 206

  Fly   271 EVPDI-TDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEE 334
              |:| |||||::||||||||:|||.|||.|||:|..|.:::||.||:::||||||||.|.:||:
Zfish   207 --PNILTDPFFVVETLCIIWFSFELIVRFFACPSKPAFFKNMMNTIDVVSIIPYFITLGTEMAED 269

  Fly   335 EDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLL 399
            .:.....|.       ...||.||||||||||||||||||||||||||||||:||||||||||||
Zfish   270 PEGGKEAKG-------GGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLL 327

  Fly   400 IFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAI 464
            ||||||||:|||||||||||..::|||.|||||||||||:|||||||||.||.:.||||||||||
Zfish   328 IFFLFIGVILFSSAVYFAEAEEKDSFFTSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAI 392

  Fly   465 AGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMM 529
            |||||||||||||||||||||||||:.:| |:|..  ..|.|.:........:.||: .|.|:.|
Zfish   393 AGVLTIALPVPVIVSNFNYFYHRETEGDE-QAQLL--TVSNPNIASDTNSSRRSSSV-VSKSEYM 453

  Fly   530 DLDDGVEST 538
            ::|:.:.::
Zfish   454 EIDEDLNNS 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	106/125 (85%)
		Ion_trans	226..488	CDD:459842	187/267 (70%)
kcna1b	XP_699869.2	BTB_POZ	32..158	CDD:453885	106/125 (85%)
		Ion_trans	161..416	CDD:459842	187/267 (70%)