DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcnd2

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001076336.1	Gene:	kcnd2 / 570188	ZFINID:	ZDB-GENE-041210-70	Length:	630	Species:	Danio rerio

Alignment Length:	421	Identity:	156/421 - (37%)
Similarity:	241/421 - (57%)	Gaps:	60/421 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLR 163
            :::||||.||:|...||.::||||||...|.. :|....|||||||....|..||.:|:: |:|.
Zfish    42 IILNVSGTRFQTWRNTLERYPDTLLGSTERDF-FFHEETNEYFFDRDPDIFRHILNFYRT-GKLH 104

  Fly   164 RPVNVPLDVFSEEIKFYE-----LGDQAINKF----REDEGFIKEEER-------PLPDNEKQRK 212
            .|.:..:..:.||:.|:.     :||....::    ||:...|:::|.       .:||...:..
Zfish   105 YPRHECISAYDEELAFFGIIPEIIGDCCYEEYKDRRRENAERIQDDEENDNNNDLVMPDLSFRES 169

  Fly   213 VWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITD 277
            :|..||.|.:|..|.|...::.|.|.:|::...:||:|              ..|..:...:::.
Zfish   170 MWRAFENPHTSTMALVFYYVTGFFIAVSVMANVVETVP--------------CGISLNRAKELSC 220

  Fly   278 ------PFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEED 336
                  .||.::|.|::.||.|..:|.:|.|::..|.:.||::||::||:||:|.|  |:.:.||
Zfish   221 GERYALAFFCLDTACVMIFTVEYLLRLIAAPSRYKFVKSVMSIIDVVAIMPYYIGL--VMTDNED 283

  Fly   337 TLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIF 401
                               :|.|.: .:|:.|||||||.||||.||:|||.|||:...|||.|:|
Zfish   284 -------------------VSGAFV-TLRVFRVFRIFKFSRHSAGLRILGYTLKSCASELGFLLF 328

  Fly   402 FLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAG 466
            .|.:.:::|::.:::||.||.:|.|.|||..||:.:|||||:|||||.|..:.|||.||:|:::|
Zfish   329 SLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIMGKIFGSICSLSG 393

  Fly   467 VLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            ||.||||||||||||:..||:....|:.::|
Zfish   394 VLVIALPVPVIVSNFSRIYHQSQRAEKRRAQ 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	36/92 (39%)
		BTB	99..182	CDD:197585	34/87 (39%)
		Ion_trans	274..488	CDD:278921	98/219 (45%)
		Ion_trans_2	403..479	CDD:285168	41/75 (55%)
kcnd2	NP_001076336.1	Shal-type	3..28	CDD:288455
		BTB	42..139	CDD:197585	36/98 (37%)
		BTB_2	42..131	CDD:280393	35/90 (39%)
		Ion_trans	228..416	CDD:278921	98/209 (47%)
		Ion_trans_2	330..410	CDD:285168	45/79 (57%)
		DUF3399	444..548	CDD:288712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810