DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and kcnb2b

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_695259.4	Gene:	kcnb2b / 566883	ZFINID:	ZDB-GENE-091113-38	Length:	831	Species:	Danio rerio

Alignment Length:	655	Identity:	207/655 - (31%)
Similarity:	307/655 - (46%)	Gaps:	128/655 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EEGGAGHGFGGG-------PQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPAR 128
            |:.|.|....||       |:..| |........||.|||.||..|...|||::.|.|.|| ..|
Zfish     3 EKAGLGVPKPGGRSVSSLPPEPIE-IIRTKARSRRVRINVGGLNHEVLWRTLDRLPRTRLG-KLR 65

  Fly   129 RLRYFDPL----------RNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEI------ 177
            .....|.|          .|||||||...:|.:||.:|:: |:|.....:....|.:|:
Zfish    66 DCNTHDSLMEVCDDYCLNENEYFFDRHPGAFTSILNFYRT-GKLHMMEEMCALSFGQELDYWGID 129

  Fly   178 ----------KFYELGDQAINKFREDEGFIKEEERPLP-DN----EKQRKVWLLFEYPESSQAAR 227
                      ::::..:|...:.|.:...::|.|.... ||    ||::|:|.|.|.|.||.||:
Zfish   130 EIYLESCCQARYHQKKEQMNEELRREAETLREREGEGEFDNTCCPEKRKKLWELLEKPSSSVAAK 194

  Fly   228 VVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTF 292
            ::||||:..|:||.|...|.||||.:....|....:..::..            :|.:||.|||.
Zfish   195 ILAIISILFIVLSTVALSLNTLPELQVTDEFGQANDNPQLAH------------VEAVCIAWFTM 247

  Fly   293 ELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMS 357
            |..:|||:.|||..|.:..:||||::||:||::|:.                ::..:||..|..:
Zfish   248 EYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIF----------------LTESNKSVLQFQN 296

  Fly   358 L-AILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGS 421
            : .::::.|::|:.||.||:|||.|||.||.||:.|..||||||.||.:|:::|||.|:|||...
Zfish   297 VRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE 361

  Fly   422 DSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 486
            |::.|.|||..||||.:|||||||||:.|..:.|||||.||.|||||.||||:|:||:||:.||.
Zfish   362 DATKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK 426

  Fly   487 RETDQE---------EMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLT 542
            .:..||         |...:|.:.|:            |........|.::||:.........||
Zfish   427 EQKRQEKAIKRREALERAKRNGSIVS------------MNLKDAFARSMELMDVTVEKSDDKRLT 479

  Fly   543 ETH--PGRSAVA----------------PFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQL 589
            :.|  |.|..:.                |..|:|:....|....|:.   :.|:....|:|:||.
Zfish   480 DNHLSPSRWGIPQRTSSDTSLRSFDKKFPNSGSQEYVHMPSPQHLNA---QNLEEMYNQMTKTQS 541

  Fly   590 YQQQQQQQQQQQNGFKQQQQQTQQQ------LQQQQSHTI----------NASAAAATSGSGSSG 638
            :.........|.....:.:.:.:.:      .||.:..||          :.::..|..|.|...
Zfish   542 FSDLSTSNSTQPAVVSKHEVELEMKEVPTAVKQQPKERTITDVRSISSVDSFASCTAEFGQGEKA 606

  Fly   639 LTMRH 643
            .|..|
Zfish   607 TTPSH 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	33/113 (29%)
		BTB	99..182	CDD:197585	32/108 (30%)
		Ion_trans	274..488	CDD:278921	101/214 (47%)
		Ion_trans_2	403..479	CDD:285168	46/75 (61%)
kcnb2b	XP_695259.4	BTB	37..143	CDD:197585	32/107 (30%)
		BTB_2	37..136	CDD:280393	32/100 (32%)
		Ion_trans	231..429	CDD:278921	101/225 (45%)
		Ion_trans_2	342..423	CDD:285168	50/80 (63%)
		Kv2channel	480..706	CDD:281514	23/135 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810