Protein Alignment Sh and kcns3a

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001122196.1
• Gene: kcns3a / 565375
• ZFINID: ZDB-GENE-080723-45
• Length: 499
• Species: Danio rerio
• Alignment Length: 493
• Identity: 148/493 - (30%)
• Similarity: 255/493 - (51%)
• Gaps: 87/493 - (17%)

  Fly   101 INVSGLRFETQLRTLNQFPDTLLGDPARRLRY-------------FDPLRNEYFFDRSRPSFDAI 152
            :||.|.:.:.:...|.:||.|.|.    ||.|             :.....||:|||:...|..:
Zfish    19 LNVGGFKQQVERVVLQRFPHTRLA----RLLYCSSEAAILQLCDDYAAADREYYFDRNPCFFRYV 79

  Fly   153 LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI-----NKFRE--------DEGFIKEEERPL 204
            |.:|.: |::.....:.:..||:|::::.:.:..:     |:|:|        |.|...:.:..|
Zfish    80 LNFYHT-GKIHLMEELCVFSFSQELEYWGIKELHLDTCCSNRFQEQKENMGDPDWGNEDDPQNQL 143

  Fly   205 PDN------------------------EKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFC 245
            .|:                        ||::::||..|.|..|::|:::|:.|:.|:|:||:..|
Zfish   144 QDSLDSSMEELSAFDKDLEKFEGTWCAEKRKELWLRLENPGYSRSAKILAVFSLSVVLISIIAMC 208

  Fly   246 LETLPEFKHYKVFNTTTNGTKIEEDEVPD-ITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCR 309
            :.::||| |.|..|         |.||.: :.|.|   ||.|::||:.|..||.:..|....|..
Zfish   209 IHSMPEF-HQKDAN---------EKEVENPVLDVF---ETFCVLWFSLEFIVRLVVTPCLRKFIC 260

  Fly   310 DVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFK 374
            :.:|:||..:|:|::.|||....:.|::..|....              .:::::||:|:|||.|
Zfish   261 NALNMIDFASIVPFYATLAFEKVDPEESEELENVG--------------RVVQILRLMRIFRILK 311

  Fly   375 LSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVT 439
            |:|||.||:.||.||:.|..|:||||.||.:|:.:||..:||.|.....|..::||..:|||.::
Zfish   312 LARHSVGLRSLGATLRHSYHEVGLLILFLSVGISIFSVLIYFVEREDHESELQTIPVGWWWATIS 376

  Fly   440 MTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE---TDQEEMQSQNFNH 501
            ||||||||..||.:.||::|:||.|.|:|.:|||:.:|.:.|:.:|.|:   .:.:::|:::...
Zfish   377 MTTVGYGDTYPVTLPGKLIGTLCIICGLLVVALPISIIFNKFSKYYQRQKALVESDQLQTEDEKQ 441

  Fly   502 V-TSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVEST 538
            . .|.|:|........|.:||:.|:|......|..:::
Zfish   442 PDLSMPFLHIADLYSQKMNSLAHSASSRSSEGDATDAS 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	36/171 (21%)
		Ion_trans	226..488	CDD:459842	100/262 (38%)
kcns3a	NP_001122196.1	BTB_POZ	15..122	CDD:453885	24/107 (22%)
		Ion_trans	189..426	CDD:459842	101/263 (38%)