DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and KCNQ5

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001153605.1	Gene:	KCNQ5 / 56479	HGNCID:	6299	Length:	951	Species:	Homo sapiens

Alignment Length:	624	Identity:	131/624 - (20%)
Similarity:	219/624 - (35%)	Gaps:	198/624 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LPKLSSQDEEGGA---------------GHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQL 112
            :|:..:..|||||               |...|.|.:..|      ....||::|.:..|.:..|
Human     1 MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVE------SGRGRVLLNSAAARGDGLL 59

  Fly   113 RTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRP-----------V 166
                     |||..|..|.                         ..||.||..           :
Human    60 ---------LLGTRAATLG-------------------------GGGGGLRESRRGKQGARMSLL 90

  Fly   167 NVPLDVFSEE-----IKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAA 226
            ..||...|.:     :|:..:.:...|..          |||        :.|..
Human    91 GKPLSYTSSQSCRRNVKYRRVQNYLYNVL----------ERP--------RGWAF---------- 127

  Fly   227 RVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFT 291
                |...||.||  |..||       ...||:|....||:       .:....::|.:.|:.|.
Human   128 ----IYHAFVFLL--VFGCL-------ILSVFSTIPEHTKL-------ASSCLLILEFVMIVVFG 172

  Fly   292 FELTV---------RFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSP 347
            .|..:         |:.....:|.|.|....|||.|.:|   .::|.|.|
Human   173 LEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLI---ASIAVVSA--------------- 219

  Fly   348 QDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIG--VVLF 410
              |:.....:.:.||.:|.:::.|:.::.|.....::||..:.|..:|   ||...:||  |::|
Human   220 --KTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKE---LITAWYIGFLVLIF 279

  Fly   411 SS-AVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPV 474
            || .||..|..::.. |.:..|..||..:|:||:||||..|:...|:::.:..|:.|:...|||.
Human   280 SSFLVYLVEKDANKE-FSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPA 343

  Fly   475 PVIVSNFN---YFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVE 536
            .::.|.|.   ...||:...|:.::...| :..|.:         :..:..|.|..:      ..
Human   344 GILGSGFALKVQEQHRQKHFEKRRNPAAN-LIQCVW---------RSYAADEKSVSI------AT 392

  Fly   537 STPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQ 601
            ..|.|...|    ..:|     .:::|..|||.....:||           :|::....::|.|:
Human   393 WKPHLKALH----TCSP-----TKKEQGEASSSKFCSNKQ-----------KLFRMYTSRKQSQK 437

  Fly   602 NGFKQQQQQTQQQLQQQQSHTINASAAAATSGSGSSGLT 640
            ..||::.:....:.|..:|.    .|:.....|.|:.:|
Human   438 LSFKERVRMASPRGQSIKSR----QASVGDRRSPSTDIT 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	17/103 (17%)
		BTB	99..182	CDD:197585	17/98 (17%)
		Ion_trans	274..488	CDD:278921	58/228 (25%)
		Ion_trans_2	403..479	CDD:285168	27/78 (35%)
KCNQ5	NP_001153605.1	Ion_trans	160..358	CDD:278921	57/221 (26%)
		Ion_trans_2	274..348	CDD:285168	25/74 (34%)
		Selectivity filter. /evidence=ECO:0000250	311..316		3/4 (75%)
		KCNQ_channel	472..659	CDD:281513	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..697
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..938
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810