DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and si:rp71-39b20.4

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_005171298.1	Gene:	si:rp71-39b20.4 / 563472	ZFINID:	ZDB-GENE-070912-704	Length:	539	Species:	Danio rerio

Alignment Length:	557	Identity:	147/557 - (26%)
Similarity:	251/557 - (45%)	Gaps:	136/557 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGEDRQHRKKQQQQQQHQ----------KEQLEQKEEQKKIAE------------------RKLQ 46
            :.:.|:|.||.::::...          .:.:|::|.....::                  :|..
Zfish     1 MDQPRRHLKKLKKRRSSLFASAKLNASFSQSIEEEESAFPFSQDSSVKPWTSMDNLDTPSPQKTD 65

  Fly    47 LREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQ 111
            .|||:             |..|.:.|..             .:||.|...  :.:||.|..|...
Zfish    66 RREQE-------------KRKSSEVEAA-------------KMPHRHSTV--INVNVGGKVFTIP 102

  Fly   112 LRTLNQFPDTLLG------DPARRLRYFDP---LRNEYFFDRSRPSFDAILYYYQSG----GRLR 163
            .....::|.|.:|      ||.::|...|.   |.||:||||....|..|.::|.|.    ....
Zfish   103 KHLAVRYPKTRIGSLALCKDPIKQLNLCDDYCVLTNEFFFDRDPTFFHYIFHFYCSNVLWVMESL 167

  Fly   164 RPVNVPLDVFSEEIKFYELG------------DQAINKFRE-----------------DEGFIKE 199
            .|||     |.||::|:.|.            ::.|::.|:                 :|||
Zfish   168 CPVN-----FEEEMQFWGLHLRDSPRCCRILYEEKIDEIRDQLKVNRELMAEIEPRHSEEGF--- 224

  Fly   200 EERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNG 264
              :.:...:.::.:|.|.|.|.||.:|:..|:.|...:|:|||...|.|:.|.|.|||:..|..
Zfish   225 --KSMFLGDVRKVLWDLIENPYSSMSAKAFAVFSSLFVLISIVAMTLNTVSELKDYKVYGRTYM- 286

  Fly   265 TKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLA- 328
                  |..:||.         |::||||..:|.|...:..:|.:..:|.:|::|::||||.|.
Zfish   287 ------ECVEITS---------ILFFTFEYFLRLLTTCDIKHFLKSALNFVDLVAVMPYFIQLVF 336

  Fly   329 TVVAEEEDTLNLPKAPVSPQD--KSSNQAMSLA-ILRVIRLVRVFRIFKLSRHSKGLQILGRTLK 390
            ...|::||        ||.||  |:..:...:: ||:|::|:|:|||.||:|||.|::..|.||:
Zfish   337 EAFADQED--------VSVQDDLKTMARVSKVSKILKVVKLMRIFRILKLARHSTGMRAFGFTLR 393

  Fly   391 ASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWG 455
            ....::..|..|:.:|:..||:.::..|.....:.|.||||.:|||.|:::||||||:.|:...|
Zfish   394 QCFEQVCCLFLFIIMGIFTFSALMHSVEQDVAGTPFSSIPDAWWWAAVSISTVGYGDVVPISYSG 458

  Fly   456 KIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQE 492
            ::|...|...|::...:|:.::.:.|:.:|.:...||
Zfish   459 RVVAFGCISFGIILNGMPISILFNKFSDYYAKLKAQE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	30/112 (27%)
		BTB	99..182	CDD:197585	29/95 (31%)
		Ion_trans	274..488	CDD:278921	72/217 (33%)
		Ion_trans_2	403..479	CDD:285168	25/75 (33%)
si:rp71-39b20.4	XP_005171298.1	BTB	90..181	CDD:295341	29/95 (31%)
		Ion_trans	287..492	CDD:278921	73/221 (33%)
		Ion_trans_2	405..486	CDD:285168	27/80 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810