DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcna2b

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001104640.1	Gene:	kcna2b / 562853	ZFINID:	ZDB-GENE-080204-89	Length:	495	Species:	Danio rerio

Alignment Length:	464	Identity:	316/464 - (68%)
Similarity:	368/464 - (79%)	Gaps:	22/464 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GGPQH-FEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDR 144
            |.||. ::|.| ||:.|||||||:|||||||||:||:|||:||||||.:|:||||||||||||||
Zfish    17 GQPQDTYDPEP-DHECCERVVINISGLRFETQLKTLSQFPETLLGDPKKRMRYFDPLRNEYFFDR 80

  Fly   145 SRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEK 209
            :|||||||||||||||||||||||.||:|||||:|||||::||..||||||||||||:.||:||.
Zfish    81 NRPSFDAILYYYQSGGRLRRPVNVTLDIFSEEIRFYELGEEAIEMFREDEGFIKEEEKLLPENEF 145

  Fly   210 QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKH-----YKVFNTTTNGTKIEE 269
            ||:|||||||||||..||::|||||.|||:|||.|||||||.|::     :|.:.|.:|.|....
Zfish   146 QRQVWLLFEYPESSGPARIIAIISVMVILISIVSFCLETLPVFRNEETDMHKAYRTDSNSTISYT 210

  Fly   270 DEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEE 334
            ...  .|||||::||||||||:||..|||.|||:|..|..::||:|||:|||||||||.|.:||:
Zfish   211 STY--FTDPFFILETLCIIWFSFEFLVRFFACPSKAGFFVNIMNIIDIVAIIPYFITLGTELAEK 273

  Fly   335 EDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLL 399
            .:           ..:...|||||||||||||||||||||||||||||||||:||||||||||||
Zfish   274 AE-----------DGQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLL 327

  Fly   400 IFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAI 464
            ||||||||:|||||||||||....|.|.||||.||||||:|||||||||.|..:.||||||||||
Zfish   328 IFFLFIGVILFSSAVYFAEADEPDSQFVSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAI 392

  Fly   465 AGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMM 529
            |||||||||||||||||||||||||:.|| |:|..| |||.|.:..:......:|..:.|.||.|
Zfish   393 AGVLTIALPVPVIVSNFNYFYHRETEGEE-QAQYLN-VTSVPKIDSSEDLKKSRSGSTMSKSDYM 455

  Fly   530 DLDDGVEST 538
            ::.:.|.::
Zfish   456 EIQEAVNNS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	74/87 (85%)
		BTB	99..182	CDD:197585	71/82 (87%)
		Ion_trans	274..488	CDD:278921	158/213 (74%)
		Ion_trans_2	403..479	CDD:285168	61/75 (81%)
kcna2b	NP_001104640.1	BTB_2	35..126	CDD:308049	76/90 (84%)
kcna2b	NP_001104640.1	Ion_trans	162..416	CDD:306908	183/266 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I952
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I890
OMA	1	1.010	-	-		QHG48093
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	1	1.000	-	-		otm24559
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3654
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010