DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh and kcna4

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_005169005.1	Gene:	kcna4 / 559036	ZFINID:	ZDB-GENE-121127-2	Length:	667	Species:	Danio rerio

Alignment Length:	569	Identity:	325/569 - (57%)
Similarity:	401/569 - (70%)	Gaps:	50/569 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QHRKKQQQQQQHQKEQ--LEQKEEQKKIA--ERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGA 75
            |..::|||||.|:..|  |.::::|:.:|  .|........|:::.|...||...:..::||...
Zfish    93 QQPQQQQQQQHHEPPQQLLRERKKQRGVARWRRNRAALGGDLRQSELALLGSEEDIMIEEEEEAE 157

  Fly    76 GH-----------GF--------------GGGPQH-FEPIPHDHDFCERVVINVSGLRFETQLRT 114
            |.           .|              ...||. :|.:.:::..|||||||||||:|||||:|
Zfish   158 GEEEEEDRKSKRSSFVYNMDDEEETVSLTDRRPQSGYENVYNEYGCCERVVINVSGLKFETQLKT 222

  Fly   115 LNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKF 179
            |.||||||||||.:|.||||||||||||||:|||||||||:|||||||:||||||.|:||||:||
Zfish   223 LAQFPDTLLGDPEKRSRYFDPLRNEYFFDRNRPSFDAILYFYQSGGRLKRPVNVPFDIFSEEVKF 287

  Fly   180 YELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIF 244
            |||||:|:.||||||||:||||:|||::|.:|::||||||||||..||.:|::||.||::|||||
Zfish   288 YELGDEAMLKFREDEGFVKEEEKPLPEDEFKRQIWLLFEYPESSSPARGIAVVSVLVIVISIVIF 352

  Fly   245 CLETLPEFKHYKVFNTT-TNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFC 308
            ||||||||:..|.|... .|.|:.:....| ..||||::||:|||||:||:.|||.|.|:|.:|.
Zfish   353 CLETLPEFRDDKEFLIPGKNSTQADNGFTP-FNDPFFIVETVCIIWFSFEIIVRFFASPSKADFF 416

  Fly   309 RDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIF 373
            ::|||.|||::|:||||||.|.:|:              |..:..||||.||||:||||||||||
Zfish   417 KNVMNTIDIVSILPYFITLGTDLAQ--------------QQGNGQQAMSFAILRIIRLVRVFRIF 467

  Fly   374 KLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVV 438
            |||||||||||||.||:||||||.||||||.|||:|||||||||||...:|.|.||||.||||||
Zfish   468 KLSRHSKGLQILGHTLRASMRELALLIFFLVIGVILFSSAVYFAEADEPTSQFTSIPDAFWWAVV 532

  Fly   439 TMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVT 503
            ||||||||||:|:.|.||||||||||||||||||||||||||||||||||||.|:..........
Zfish   533 TMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDNEDQAPAVEQPPP 597

  Fly   504 SCPYLPGTLGQHM---KKSSLSESSSDMMDLDDGV-ESTPGLTETHPGR 548
            .|||.|..|.:..   ..|||.:.:::.|::::|| ||..|.....|.|
Zfish   598 GCPYFPDFLRKFKGSPSGSSLGDKAAEYMEMEEGVTESLCGGDTQSPSR 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	74/87 (85%)
		BTB	99..182	CDD:197585	70/82 (85%)
		Ion_trans	274..488	CDD:278921	151/213 (71%)
		Ion_trans_2	403..479	CDD:285168	62/75 (83%)
kcna4	XP_005169005.1	K_channel_TID	1..70	CDD:311753
		BTB_2	207..295	CDD:308049	74/87 (85%)
		Ion_trans	382..582	CDD:306908	152/214 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I952
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I890
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D307298at33208
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101149
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870