Protein Alignment Sh and kcnf1a

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001076280.1
• Gene: kcnf1a / 557280
• ZFINID: ZDB-GENE-041001-217
• Length: 494
• Species: Danio rerio
• Alignment Length: 483
• Identity: 144/483 - (29%)
• Similarity: 237/483 - (49%)
• Gaps: 95/483 - (19%)

  Fly    99 VVINVSGLRFETQLRTLNQFPDTLLGDPARRLR-----------YFDPLRNEYFFDRSRPSFDAI 152
            :.:|:.|::.......||::|:|.|.:...|:.           .:|.|:.|::|||...:|..|
Zfish    23 ISVNIGGVKHTLYGDVLNRYPETRLAELLNRVSDSAEDLSGLCDDYDDLKREFYFDRDPKAFKCI 87

  Fly   153 --LYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQ--------AINKFREDEGFIKEEERPLPDN 207
              ||||   |.:.....:....|.:|:.::.:.:.        ::|:...:...|.|:.:.:.|:
Zfish    88 LELYYY---GEIHMKRGICPMCFMKEMDYWGIDEDYLDECCRCSLNEVETELAEIAEKVKTILDD 149

  Fly   208 EK----------------QRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYK 256
            .:                |..:|.|.|.||||.||||:|::|...||||.|:.|:.|:||.
Zfish   150 LEDDDDDDDARVSRSQRCQTFLWKLMEKPESSVAARVIAVVSFVFILLSSVVMCVGTIPEL---- 210

  Fly   257 VFNTTTNGTKIEEDEVPDITDPFF-LIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAI 320
                     ::::||......|.. .|||.||||||.|..:|..:..:||:|....:|:||.:||
Zfish   211 ---------QVQDDEGHLTEHPTLEAIETACIIWFTVEYVLRLASSSSKLHFVFSFLNIIDFLAI 266

  Fly   321 IPYFIT-----LATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSK 380
            :|:::.     |.|.:.|   ..|:.:|                 ::.:|::|:.|||||:|||.
Zfish   267 MPFYVVLILTHLGTAMME---LANVQQA-----------------VQALRIMRIARIFKLARHSS 311

  Fly   381 GLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGY 445
            |||.|...||:|::|||||:.::.:|:.|||:..|..|.....:.|.|||.:||||::|||||||
Zfish   312 GLQTLTFALKSSLKELGLLLMYMSVGIFLFSALGYTMEQSHPETMFTSIPQSFWWAIITMTTVGY 376

  Fly   446 GDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRET--------DQEEMQSQNFNHV 502
            ||:.|....|:...::..:.||:.||||:..|::||...|.::.        :.|.|..:.....
Zfish   377 GDIYPKTTLGRCNAAVSFLCGVIAIALPIHPIINNFVIVYSKQRVLETAAKHEIELMALRAREEA 441

  Fly   503 TSCPYLPGTLGQHMKKSSLSESSSDMMD 530
            ..||        ..::.:.|..||.|.|
Zfish   442 QECP--------EAERRAASVDSSSMWD 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	33/160 (21%)
		Ion_trans	226..488	CDD:459842	99/267 (37%)
kcnf1a	NP_001076280.1	BTB_POZ_Kv5_KCNF1	21..136	CDD:349690	24/115 (21%)
		Ion_trans	184..420	CDD:459842	99/268 (37%)