Protein Alignment Sh and KCNK9

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001269463.1
• Gene: KCNK9 / 51305
• HGNCID: 6283
• Length: 374
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 44/213 - (20%)
• Similarity: 87/213 - (40%)
• Gaps: 30/213 - (14%)

  Fly   387 RTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPV 451
            |....||..:..:.||..:|.:...:|. |::. .|.|||    .|:::..:|:||:|:||...:
Human   150 RNTDVSMENMVTVGFFSCMGTLCIGAAA-FSQC-EEWSFF----HAYYYCFITLTTIGFGDYVAL 208

  Fly   452 GVWGKI--------VGSLCAIAGVLTIALPVPVIVSNFNYFYHRE--TDQEEMQSQNFNHVTSCP 506
            ...|.:        ...:..:.|:..|...:.::|..|......:  .|.||..|...|..:...
Human   209 QTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVI 273

  Fly   507 YLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSM 571
            ::|     ...:.|.....:|:.||......|...::.:.||| |||        |...::.|:.
Human   274 HIP-----EEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRS-VAP--------QNSFSAKLAP 324

  Fly   572 SIDKQLQHPLQQLTQTQL 589
            .....:.:.:::::.:.|
Human   325 HYFHSISYKIEEISPSTL 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885
		Ion_trans	226..488	CDD:459842	24/108 (22%)
KCNK9	NP_001269463.1	Ion_trans_2	<73..132	CDD:462301
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98
		Ion_trans_2	<183..243	CDD:462301	14/63 (22%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204		2/4 (50%)
		X-gate. /evidence=ECO:0000269|PubMed:38630723	243..248		2/4 (50%)