Protein Alignment Sh and kcna5

DIOPT Version :10

• Sequence 1: NP_728123.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_004912856.2
• Gene: kcna5 / 496997
• XenbaseID: XB-GENE-6037401
• Length: 616
• Species: Xenopus tropicalis
• Alignment Length: 597
• Identity: 325/597 - (54%)
• Similarity: 388/597 - (64%)
• Gaps: 125/597 - (20%)

  Fly     9 GLGEDRQHRKKQQQQQQHQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEG 73
            |..|:......||||||:|.                             .|.|          :.
 Frog    54 GRQEEGSGESCQQQQQQYQP-----------------------------PGTG----------QA 79

  Fly    74 GAGHGFGGGPQHFEPI---------------------------PH-------------------- 91
            |.|...|||..|..|.                           ||
 Frog    80 GGGGCRGGGVGHHLPSNDMIMSHPGSTIKECDIETVIRLEEEEPHAQQHSHHHPEEEEDHQFDLG 144

  Fly    92 --DHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILY 154
              ||:..:||:||::||||||||.|||||||||||||.:|:|:||||||||||||:|||||.|||
 Frog   145 IMDHESNQRVIINIAGLRFETQLSTLNQFPDTLLGDPEKRMRFFDPLRNEYFFDRNRPSFDGILY 209

  Fly   155 YYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEY 219
            :|||||::||||||.:|||::||:|||||::|:.:|||||||||:||:|||.||.||:|||:|||
 Frog   210 FYQSGGKIRRPVNVSIDVFADEIRFYELGEEAMERFREDEGFIKDEEKPLPCNEFQRQVWLIFEY 274

  Fly   220 PESSQAARVVAIISVFVILLSIVIFCLETLPEFKH--------YKVFNTTTNGTKIEEDEVP--D 274
            ||||.:||.:||:||.|||:||:.|||||||||:.        .||.|.|      :|...|  .
 Frog   275 PESSSSARGIAIVSVLVILISIITFCLETLPEFRDENELPPALSKVLNDT------QEHPSPPSG 333

  Fly   275 ITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLN 339
            :|||||:|||.|:|||||||.|||.|||:|.:|.:::||:|||:|||||||||.|.:|:.
 Frog   334 LTDPFFIIETTCVIWFTFELLVRFFACPSKSDFSKNIMNIIDIVAIIPYFITLGTELAQH----- 393

  Fly   340 LPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLF 404
                    |..:..|||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog   394 --------QTNNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF 450

  Fly   405 IGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLT 469
            |||:|||||||||||....|.|.|||||||||||||||||||||.||.|.|||||||||||||||
 Frog   451 IGVILFSSAVYFAEADDPESHFSSIPDAFWWAVVTMTTVGYGDMRPVTVGGKIVGSLCAIAGVLT 515

  Fly   470 IALPVPVIVSNFNYFYHRETDQEE---MQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDL 531
            |||||||||||||||||||||.||   ::.::.:...||   .|.|.:...::|||:|..  ::.
 Frog   516 IALPVPVIVSNFNYFYHRETDHEEQVMLKEESSSRQGSC---AGDLKRSPSRASLSKSVH--LEN 575

  Fly   532 DDGVESTPGLTE 543
            .:|:.:..|..|
 Frog   576 IEGINNGTGSLE 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_728123.1	BTB_POZ	97..223	CDD:453885	95/125 (76%)
		Ion_trans	226..488	CDD:459842	189/271 (70%)
kcna5	XP_004912856.2	BTB_POZ	152..278	CDD:453885	95/125 (76%)
		Ion_trans	281..534	CDD:459842	189/271 (70%)