DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sh and Shal

DIOPT Version :9

Sequence 1:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	160/445 - (35%)
Similarity:	242/445 - (54%)	Gaps:	84/445 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PIPHDH----DFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPS 148
            |:|.|.    |  |:::|||||.||||...||.::||||||...|.. ::|....||||||....
  Fly    30 PMPKDRRKTDD--EKLLINVSGRRFETWRNTLEKYPDTLLGSNEREF-FYDEDCKEYFFDRDPDI 91

  Fly   149 FDAILYYYQSGGRLRRPVNVPLDVFSEEIKFY-----ELGDQAINKFREDEGFIKEEERPLPDNE 208
            |..||.||:: |:|..|.:..|..:.||:.|:     .:||.....:|:.:   :|....|.|::
  Fly    92 FRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRK---RENAERLMDDK 152

  Fly   209 --------------KQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLE------------ 247
                          .::|:|..||.|.:|.:|.|...::.|.|.:|::...:|
  Fly   153 LSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAG 217

  Fly   248 TLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVM 312
            |||..:.||:.                    ||.::|.|::.||.|..:|..|.|::..|.|.||
  Fly   218 TLPCGERYKIV--------------------FFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVM 262

  Fly   313 NVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSR 377
            ::||::||:||:|.|.                ::..|..|...::|      |:.|||||||.||
  Fly   263 SIIDVVAIMPYYIGLG----------------ITDNDDVSGAFVTL------RVFRVFRIFKFSR 305

  Fly   378 HSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTMTT 442
            ||:||:|||.|||:...|||.|:|.|.:.:::|::.:::||...:.:.|.|||..||:.:|||||
  Fly   306 HSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTT 370

  Fly   443 VGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQ 497
            :|||||.|..:.|||||.:|:::|||.||||||||||||:..||:....::.::|
  Fly   371 LGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQ 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	39/92 (42%)
		BTB	99..182	CDD:197585	37/87 (43%)
		Ion_trans	274..488	CDD:278921	94/213 (44%)
		Ion_trans_2	403..479	CDD:285168	38/75 (51%)
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	45/120 (38%)
		Ion_trans	188..415	CDD:395416	102/268 (38%)
		DUF3399	445..540	CDD:403174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
	5	4.840