Protein Alignment Sh and KCNS3

DIOPT Version :9

• Sequence 1: NP_001303569.1
• Gene: Sh / 32780
• FlyBaseID: FBgn0003380
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001269357.1
• Gene: KCNS3 / 3790
• HGNCID: 6302
• Length: 491
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 157/498 - (31%)
• Similarity: 241/498 - (48%)
• Gaps: 98/498 - (19%)

  Fly    97 ERVVINVSGLRFETQLRTLNQFPDTLLG------DPARRLRYFDPLR---NEYFFDRSRPSFDAI 152
            |.|.:||.|.:......||.:||.|.||      .....|...|...   .||:|||:...|..:
Human    15 ELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYV 79

  Fly   153 LYYYQSGGRLRRPVNVPLDVFS--EEIKFYELGDQAI---------------------------- 187
            |.:|.:|   :..|...|.|||  :||:::.:.:..|
Human    80 LNFYYTG---KLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVS 141

  Fly   188 --NKFREDEGFIKEEER--PLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLET 248
              :.|.|...|.||.|:  .|...:.::|:|:..|.|....:|:::||.|:.|:|.|||..|:.:
Human   142 TDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHS 206

  Fly   249 LPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFL-IETLCIIWFTFELTVRFLACPNKLNFCRDVM 312
            :.||                ::|..::.||... :|..||.|||.||.||..|.|.:..|.::.:
Human   207 MSEF----------------QNEDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPL 255

  Fly   313 NVIDIIAIIPYFITLATVVAEE--EDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKL 375
            |:||.::|||::.|||....||  ||..|:.|                 :::::||:|:|||.||
Human   256 NIIDFVSIIPFYATLAVDTKEEESEDIENMGK-----------------VVQILRLMRIFRILKL 303

  Fly   376 SRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSDSSFFKSIPDGFWWAVVTM 440
            :|||.||:.||.||:.|..|:|||:.||.:|:.:||..:|..|....:|...|||..:|||.::|
Human   304 ARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISM 368

  Fly   441 TTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSC 505
            |||||||..||.:.||::.|.|.|.|:|.:|||:.:|.:.|:.:|.::.|.:..|... :....|
Human   369 TTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSE-DAPEKC 432

  Fly   506 PYLP-----GTLGQHMKK--SSLSE--------SSSDMMDLDD 533
            ..||     ....|.|..  :|||.        .|:|...::|
Human   433 HELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIED 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393	29/98 (30%)
		BTB	99..182	CDD:197585	29/93 (31%)
		Ion_trans	274..488	CDD:278921	89/216 (41%)
		Ion_trans_2	403..479	CDD:285168	34/75 (45%)
KCNS3	NP_001269357.1	BTB_2	17..116	CDD:280393	30/101 (30%)
		BTB	44..122	CDD:197585	19/80 (24%)
		Ion_trans	219..417	CDD:278921	89/214 (42%)
		Ion_trans_2	329..411	CDD:285168	36/81 (44%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810